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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539070/
Jul 12, 2012 · Intranasal delivery of the cationic PLGA particles containing FMDV DNA vaccine formulations enhanced protective immunity against FMDV . Whilst DNA vaccines have been shown promise for intranasal vaccine delivery, the technology requires further research to …Author: Mehfuz Zaman, Saranya Chandrudu, Istvan Toth
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846493/
In other countries, much cheaper multidose bottles are the mainstay, which may be also used for intranasal vaccines. The price for a vaccine, its primary packaging and the delivery device is not equal to the cost for vaccination.
https://www.sciencedirect.com/science/article/pii/S0168365916301079
Based on these properties, we assume that cyclodextrin-PEI (CP) polymer may serve as an efficient carrier for nasal mRNA vaccine delivery. Here, we report the synthesis of CP polymer and the fabrication of a CP polymer-based intranasal delivery platform for mRNA vaccine. The HIV glycoprotein 120 (gp120) was selected as a model antigen.Author: Man Li, Mengnan Zhao, Yao Fu, You Li, Tao Gong, Zhirong Zhang, Xun Sun
http://www.biopharminternational.com/innovations-intranasal-vaccine-delivery-technology
Oct 01, 2009 · Innovative delivery technologies for the needle-free delivery of vaccines by the intranasal route offer advantages to traditional parenteral needle-based delivery systems developed and produced by the vaccine industry. Dry powder intranasal vaccine technologies have recently been developed. In addition, a rapid manufacturing technology platform ...
https://www.webmd.com/a-to-z-guides/prevention-15/vaccines/flu-vaccine-which-type
Flu Shot or Nasal Spray? Reviewed by Carol DerSarkissian on September 09, 2019. When it comes to the flu vaccine, the question for almost everyone shouldn't be if you should get it, but how you ...
https://www.cdc.gov/vaccines/hcp/vis/vis-statements/flulive.html
Aug 15, 2019 · Live, Intranasal Influenza Vaccine Information Statement. Tell your vaccine provider if the person getting the vaccine: Is younger than 2 years or older than 49 years of age.; Is pregnant.; Has had an allergic reaction after a previous dose of influenza vaccine, or has any severe, life-threatening allergies.; Is a child or adolescent 2 through 17 years of age who is receiving aspirin or ...
http://www.optinose.com/wp-content/uploads/2003/01/20030129173426_Nasal_delivery_of_vaccines.pdf
of intranasal administration and injection may be preferable for optimal protection, especially when an inactivated vaccine is used. This can be achieved by giving an initial injection ‘priming’ the immune response, followed by one or more nasal vaccinations to ‘boost’ the response. 400 Nasal Delivery of Vaccines 300 200 100
http://www.bluewillow.com/
In 2020, BlueWillow will initiate Phase 1 human studies for two intranasal vaccine programs — pandemic flu and anthrax — both of which will be funded by NIH. The company has also demonstrated that it’s nanotechnology platform can be used to develop intranasal immunotherapy (INIT) for food and respiratory allergies.
https://www.globenewswire.com/news-release/2020/02/28/1992600/0/en/Altimmune-Completes-First-Development-Milestone-Toward-a-Single-Dose-Intranasal-COVID-19-Vaccine.html
Feb 28, 2020 · A recent Phase 2 clinical study with NasoVAX highlighted the ability of intranasal vaccine delivery to stimulate a durable and broad immune response against the influenza virus.Author: Altimmune, Inc.
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