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https://www.ncbi.nlm.nih.gov/pubmed/2862235
Intranasal drug delivery by spray and drops. Hardy JG, Lee SW, Wilson CG. A solution of 99mTc-labelled human serum albumin was administered into the nose as a spray and as one or three drops. The patterns of deposition and the rates of clearance in …Author: J. G. Hardy, S. W. Lee, C. G. Wilson
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.2042-7158.1985.tb05069.x
The single drop spread more extensively than the spray, while the three drops were sufficient to cover most of the walls of the nasal cavity. Clearance was faster following administration of the drops. These factors have implications when designing dosage regimens for …Author: J. G. Hardy, S. W. Lee, C. G. Wilson
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539067/
Oct 18, 2012 · Nasal drug delivery devices: characteristics and performance in a clinical perspective—a review ... studies have assessed deposition patterns with dyes with the goal of improving deposition and the clinical outcome of delivery with spray pumps and drops ... Intranasal drug delivery by spray and drops. J Pharm Pharmacol. 1985; 37:294–297 ...Author: Per Gisle Djupesland
http://intranasal.net/Overview/default.htm
Therapeutic Intranasal Drug Delivery ... Intranasal drug delivery - General Principles (click here) ... In addition, research has demonstrated that clearance of spray is much slower than clearance of drops[4] since much of the spray deposits on nonciliated areas, whereas nose drop solutions are primarily distributed on ciliated surfaces. ...
http://intranasal.net/DeliveryTechniques/
Feb 28, 2020 · Drug delivery as drops using a syringe or dropper. A second method of intranasal drug delivery is to take a solubilized medication (liquid form) and drip it into the nose a few drops at a time, allowing it to run down onto the nasal mucosa.
https://www.deepdyve.com/lp/wiley/intranasal-drug-delivery-by-spray-and-drops-wMxUsIOODp
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