We have collected information about Intra-Articular Drug Delivery for you. Follow the links to find out details on Intra-Articular Drug Delivery.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015522/
Introduction. Intra-articular (IA) drug delivery presents many advantages as it offers direct access to the joint space, thus increasing the bioavailability of therapeutic agents at the affected site while reducing systemic exposure, potential side effects and overall cost.Author: Muhammad Farooq Rai, Christine T.N. Pham
https://www.ncbi.nlm.nih.gov/pubmed/29792929
To satisfy this unmet medical need, drug delivery systems (DDSs) containing disease-modifying OA drugs (DMOADs) for intra-articular (IA) administration are required to improve the health of OA patients. DDSs should provide controlled and/or sustained drug release, enabling long-term treatment with a reduced number of injections.Author: Pierre Maudens, Olivier Jordan, Eric Allémann
https://www.nature.com/articles/s41584-018-0123-4
Nov 29, 2018 · Intra-articular drug delivery has a number of advantages over systemic administration; however, for the past 20 years, intra-articular treatment options for …Author: Ian A. Jones, Ryan Togashi, Melissa L. Wilson, Nathanael Heckmann, C. Thomas Vangsness
https://www.sciencedirect.com/science/article/pii/S1359644618300461
Introduction. Osteoarthritis (OA) is the most common type of arthritis and degenerative joint disease. OA is a leading cause of chronic disability and progressively affects cartilage, the synovial membrane, bone and periarticular tissues 1, 2, 3.Knees, hips, fingers and the lower spine region are frequently affected by the occurrence of OA inducing chronic pain, inflammation and stiffness.Author: Pierre Maudens, Olivier Jordan, Eric Allémann
https://www.hindawi.com/journals/jnt/2012/748909/
The objective of this paper is to provide readers with current developments of intra-articular drug delivery systems. In recent years, although the search for a clinically successful ideal carrier is ongoing, sustained-release systems, such as polymeric micro- and nanoparticles, liposomes, and hydrogels, are being extensively studied for intra-articular drug delivery purposes. The advantages ...Author: Zhiyue Zhang, Guihua Huang
http://www.eurekaselect.com/92876/article
The utilization of the intra-articular route for the delivery of drugs and other macromolecules has recently evolved making use of the avascularity of the cartilage tissue to allow regional administration of the drug within the joint space rather than the systemic circulation.Author: Maha Nasr Sayed Aly
https://www.aiche.org/resources/publications/cep/2018/may/designing-drug-delivery-systems-articular-joints
Intra-articular injection is commonly used for local drug delivery into knee joints. However, upon injection into the fluid-filled joint capsule encased in the synovial membrane (or synovium), the drug is typically lost to systemic circulation within a matter of hours to days.
https://www.researchgate.net/publication/23656785_Intra-Articular_Drug_Delivery_A_Fast_Growing_Approach
The utilization of the intra-articular route for the delivery of drugs and other macromolecules has recently evolved making use of the avascularity of the cartilage tissue to allow regional ...Author: Maha Nasr
https://www.outsourcestrategies.com/blog/cpt-code-updates-impacting-orthopedics-in-2020.html
20705 Removal of drug-delivery device(s), intra-articular (List separately in addition to primary procedure) Coding drug delivery implantations – points to note. These services are add-on codes and always reported in conjunction with other procedures. The primary codes with which the add-on codes can be reported are indicated in the ...
https://www.nature.com/articles/nrrheum.2016.210
Current intra-articular drug delivery methods do not guarantee sufficient drug penetration into cartilage tissue to reach cell and matrix targets at the concentrations necessary to elicit the ...Author: Ambika G. Bajpayee, Alan J. Grodzinsky
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