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https://www.nature.com/articles/s41584-018-0123-4
Nov 29, 2018 · Intra-articular drug delivery has a number of advantages over systemic administration; however, for the past 20 years, intra-articular treatment options for the management of knee osteoarthritis (OA) have been limited to analgesics, glucocorticoids, hyaluronic acid (HA) and a small number of unproven alternative therapies.Author: Ian A. Jones, Ryan Togashi, Melissa L. Wilson, Nathanael Heckmann, C. Thomas Vangsness
https://www.ncbi.nlm.nih.gov/pubmed/29792929
To satisfy this unmet medical need, drug delivery systems (DDSs) containing disease-modifying OA drugs (DMOADs) for intra-articular (IA) administration are required to improve the health of OA patients. DDSs should provide controlled and/or sustained drug release, enabling long-term treatment with a reduced number of injections.Author: Pierre Maudens, Olivier Jordan, Eric Allémann
https://www.sciencedirect.com/science/article/pii/S0169409X06000160
Osteoarthritis (OA) is a primarily non-inflammatory, degenerative joint disease characterized by progressive loss of articular cartilage, subchondral bone sclerosis, osteophyte formation, changes in the synovial membrane, and an increased volume of synovial fluid with reduced viscosity and hence changed lubrication properties.Author: Nicole Gerwin, Caroline Hops, Andrea Lucke
https://www.sciencedirect.com/science/article/pii/S1359644618300461
S. Colen, et al.Comparison of intra-articular injections of hyaluronic acid and corticosteroid in the treatment of osteoarthritis of the hip in comparison with intra-articular injections of bupivacaine. Design of a prospective, randomized, controlled study with …Author: Pierre Maudens, Olivier Jordan, Eric Allémann
https://www.researchgate.net/publication/7205668_Intra-articular_drug_delivery_in_osteoarthritis_Adv
Osteoarthritis (OA) is a primarily non-inflammatory, degenerative joint disease characterized by progressive loss of articular cartilage, subchondral bone sclerosis, osteophyte formation, changes in the synovial membrane, and an increased volume of synovial fluid with reduced viscosity and hence changed lubrication properties.
https://www.tandfonline.com/doi/abs/10.1517/17425247.2014.867325
Jan 09, 2009 · Introduction: Intra-articular (IA) drug delivery is very useful in the treatment of osteoarthritis (OA), the most common chronic joint affliction. However, the therapeutic effect of IA administration depends mostly on the efficacy of drug delivery. Areas covered: The present article reviews the current status of IA therapy for OA treatment as well as its rationale.Author: Mi Lan Kang, Gun-Il Im
https://pubs.acs.org/doi/10.1021/acsabm.9b00232
The most common treatment for osteoarthritis is daily oral administration of a nonsteroidal anti-inflammatory drug such as diclofenac. This daily dosage regime is often associated with severe side effects. In this study, we explored the potential of utilizing a high molecular weight cross-linked polyurethane polymer covalently linked to diclofenac (C-DCF-PU) for intra-articular administration ...Author: Adrian Sulistio, Friederike M. Mansfeld, Friederike M. Mansfeld, Felisa Reyes-Ortega, Asha M. D’Souz...
https://www.researchgate.net/publication/264502552_Progress_in_Intra-Articular_Drug_Delivery_Systems_for_Osteoarthritis
To guarantee the efficacy and avoid frequent injections, rationally designed intra-articular drug delivery systems (DDSs), which may remain in OA joints for a long time and sustainedly release ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015522/
Intra-articular (IA) injections directly deliver high concentrations of therapeutics to the joint space and are routinely used in various musculoskeletal conditions such as osteoarthritis (OA) and rheumatoid arthritis …Author: Muhammad Farooq Rai, Christine T.N. Pham
https://www.nature.com/articles/nrrheum.2016.210
Current intra-articular drug delivery methods do not guarantee sufficient drug penetration into cartilage tissue to reach cell and matrix targets at the concentrations necessary to elicit the desired biological response.Author: Ambika G. Bajpayee, Alan J. Grodzinsky
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