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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638190/
Nov 02, 2015 · The host interferon (IFN) response represents one of the first barriers that influenza viruses must surmount in order to establish an infection. Many advances have been made in recent years in understanding the interactions between influenza viruses and the interferon system.Author: Marian J. Killip, Marian J. Killip, Ervin Fodor, Richard E. Randall
https://www.ncbi.nlm.nih.gov/pubmed/31110361/
Leukotriene B4-type I interferon axis regulates macrophage-mediated disease tolerance to influenza infection. ... (IAV) infection depends not only on host resistance to eliminate the virus, but also disease tolerance to limit lung tissue damage and maintain pulmonary function. ... the delivery of a single dose of LTB4 at the peak viral load ...Author: Erwan Pernet, Erwan Pernet, Jeffrey Downey, Jeffrey Downey, Donald C. Vinh, Donald C. Vinh, William ...
https://www.sciencedirect.com/science/article/pii/S0042682205006100
In the current study we show that influenza A and B viruses induce only weak cytokine and chemokine response in human A549 lung epithelial cells. Most importantly, we demonstrate here that influenza-A-virus-induced chemokine response can be greatly enhanced by pretreating cells with TNF-α or IFN-α prior to virus infection.Author: Ville Veckman, Pamela Österlund, Riku Fagerlund, Krister Melén, Sampsa Matikainen, Ilkka Julkunen
https://www.sciencedirect.com/science/article/pii/S0168170215000568
Furthermore, activation of the IFN response could not be detected within some developing influenza virus plaques in lung epithelial cells (Chen et al., 2010). This may also be the case for influenza viruses that do not express a functional NS1 protein and therefore lack the principal viral IFN antagonist.Author: Marian J. Killip, Marian J. Killip, Ervin Fodor, Richard E. Randall
https://medicalxpress.com/news/2016-09-interferon-flu-therapy.html
Sep 07, 2016 · The team hope interferon lambda's existing safety profile means that if a new pandemic influenza strain hit the population in the near future, it might be considered as a treatment option.
https://www.tandfonline.com/doi/pdf/10.1080/17425247.2018.1503251
tics with topical lung delivery are finally reaching the clinic – especially since 2010 (Table 1). To the best of our knowledge, 18 inhaled protein therapeutics have entered clinical trials and are being tested in either major respiratory diseases (asthma and pneumonia) or in rare/orphan lung diseases (e.g. cysticAuthor: Elsa Bodier-Montagutelli, Alexie Mayor, Laurent Vecellio, Renaud Respaud, Nathalie Heuzé-Vourc’h
https://www.nature.com/articles/mi201741
May 17, 2017 · Increased levels of interferon-γ (IFN-γ) are routinely observed in the respiratory tract following influenza virus infection, yet its potential role remains unclear. We now demonstrate that ...Author: D Califano, Y Furuya, S Roberts, D Avram, D Avram, A N J McKenzie, D W Metzger
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