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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086622/
Integrin targeted delivery of therapeutic peptide and proteins. The second approach relies on the conjugation of integrin ligands with therapeutic biologically relevant biomolecules, such as peptides and proteins, to target them to the specific site for their action.Author: Zhaofei Liu, Fan Wang, Xiaoyuan Chen
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161715/
A promising strategy to develop novel targeted drug delivery systems is the targeting and exploitation of activated neutrophils. Here, we review a new drug delivery platform based on neutrophils. There are two types of drug delivery systems: neutrophils as carriers and neutrophil membrane-derived nanovesicles.Author: Dafeng Chu, Xinyue Dong, Xutong Shi, Canyang Zhang, Zhenjia Wang
https://www.sciencedirect.com/science/article/pii/S1549963416302246
Foot-and-mouth disease virus-like particles as integrin-based drug delivery system achieve targeting anti-tumor efficacy. ... the potential of FMDV VLPs as a platform for specific targeted delivery of drugs or chemical reagents. ... modification did not affect the ability of FMDV VLPs to bind to integrin receptors. As drug delivery agents, VLPs ...Author: Dan Yan, Zhidong Teng, Shiqi Sun, Shan Jiang, Hu Dong, Yuan Gao, Yanquan Wei, Wenwu Qin, Xiangtao Li...
https://www.cell.com/cancer-cell/fulltext/S1535-6108(02)00238-6
Jan 01, 2003 · The fibrinogen receptor, integrin α2bβ3, is therefore a candidate radiation-inducible receptor for site-specific drug delivery. Drug delivery systems targeted to radiation-induced receptor Drug delivery vehicles such as liposomes and nanoparticles can be conjugated to fibrinogen to accomplish site-specific binding to irradiated tumor blood ...Author: Dennis Hallahan, Ling Geng, Shimian Qu, Christopher Scarfone, Todd Giorgio, Edwin Donnelly, Xiang Ga...
https://www.nature.com/articles/s41467-019-14000-9
Jan 08, 2020 · A hurdle to the use of materials for cell delivery is the lack of understanding of material properties that govern transplanted stem cell functionality. ... Integrin-specific hydrogels have ...Author: Amy Y. Clark, Karen E. Martin, José R. García, Christopher T. Johnson, Hannah S. Theriault, Woojin M...
https://mct.aacrjournals.org/content/15/6/1291
Jun 01, 2016 · These results demonstrate integrin-targeting specificity of drug delivery mediated by 2.5F–Fc–MMAF and suggest that conjugation of MMAF to CTRL-Fc, which does not bind integrins, reduces nonspecific activity of free drug.Author: Nicolas V. Currier, Shelley E. Ackerman, James R. Kintzing, Rishard Chen, Maria Filsinger Interrante...
https://www.sciencedirect.com/science/article/pii/S0169409X15002860
Advancement in integrin facilitated drug delivery ... and we have emphasised in specific sections those addressing the medical needs of drug delivery to brain tumours, as well as the delivery of oligonucleotides modulating gene-dependent pathological mechanism. The latter could constitute the basis of a promising third branch in the therapeutic ...Author: Daniela Arosio, Cesare Casagrande
https://www.mdpi.com/2306-5354/5/4/76/htm
Integrin specific accumulation of the conjugate was observed in vivo with significant tumor uptake at 2 h post-injection in mice bearing orthotopic MDA-MB-435 tumors. ... N. Synthesis and biological evaluation of dimeric RGD peptide-paclitaxel conjugate as a model for integrin-targeted drug delivery. J. Med. Chem. 2005, 48, 1098–1106.Author: Poulami Majumder
https://www.nature.com/articles/s41598-017-15012-5
Nov 07, 2017 · The specific affinity of RGD sequence and integrin (α v β 3) has also been harnessed for targeted drug delivery 16,17 and diagnostic applications using nanoparticles 18,19. The expression of ...Author: Anish Babu, Narsireddy Amreddy, Ranganayaki Muralidharan, Gopal Pathuri, Hariprasad Gali, Allshine C...
https://www.researchgate.net/publication/311478846_Cancer_Cell_Specific_Delivery_of_Photosystem_I_Through_Integrin_Targeted_Liposome_Shows_Significant_Anticancer_Activity
Cancer Cell Specific Delivery of Photosystem I Through Integrin Targeted Liposome Shows Significant Anticancer Activity Article in ACS Applied Materials & Interfaces 9(1) · December 2016 with 50 ...
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