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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787057/
Technologies are being explored to make the noninvasive delivery of insulin possible. Some of the routes of insulin administration that are under investigation are oral, buccal, nasal, peritoneal and transdermal. This review article focuses on the past, present and future of various insulin delivery techniques.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581917/
The first closed-loop insulin delivery system adopting subcutaneous insulin delivery route has been approved by the US Food and Drug Administration based on a recent pivotal study. Limitations remain with regards to delays in insulin absorption and action inherently linked to the subcutaneous route of …Author: Lia Bally, Hood Thabit, Roman Hovorka
https://care.diabetesjournals.org/content/3/2/219
Mar 01, 1980 · The relative merits of intraperitoneal (i.p.) and subcutaneous (s.c.) insulin delivery compared with intravenous (i.v.) delivery were investigated in seven diabetic patients using a combination of glucosecontrolled closed-loop (Biostator) and portable open-loop (Siemens minipump) insulin infusion systems. With appropriate algorithms for feedback-controlled insulin infusion, it could be shown ...Author: Karl Irsigler, Harrald Kritz
https://diabetes.diabetesjournals.org/content/28/12/1069
Dec 01, 1979 · Compared with the i.v. and s.c. routes of insulin delivery, only 50% of the i.p. delivered insulin appeared in the plasma. The onset of the biologic activity of the insulin delivered by the three different routes during the 4½-h observation period was most rapid for …Author: Schade Ds, Eaton Rp, Friedman N, Spencer W
https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1464-5491.2003.01076.x
To date, attempts to exploit the nasal, oral, gastrointestinal and transdermal routes have been mainly unsuccessful. The respiratory tree, with a large surface area, offers the greatest potential for the delivery of polypeptide drugs and there is renewed interest in administrating insulin by the intrapulmonary route.Author: D. R. Owens, B. Zinman, G. Bolli
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