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https://www.sciencedirect.com/science/article/abs/pii/S0169409X02001163
Nov 01, 2002 · The favourable drug delivery properties of microemulsions appear to mainly be attributed to the excellent solubility properties. However, the vehicles may also act as penetration enhancers depending on the oil/surfactant constituents, which involves a risk of inducing local irritancy.Author: Mads Kreilgaard
https://www.researchgate.net/publication/11009379_Influence_of_microemulsion_on_cutaneous_drug_delivery
Microemulsions, in generall may improve the solubility of a drug in the skin, disrupt the lipid barrier of the stratum corneum, increase skin hydration and en- able better movement into or across ...Author: Mads Kreilgaard
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978525/
Feb 28, 2014 · It is important to bear in mind that the formulation is not the only factor to influence this balance; drug characteristics also influence its fate and whether a more pronounced deep skin retention or absorption into the circulation will occur . In the following sections, we will provide examples of microemulsion use to favor either cutaneous or transdermal delivery based on the site of action …Author: Luciana Biagini Lopes
https://kundoc.com/pdf-influence-of-microemulsions-on-cutaneous-drug-delivery-.html
Furthermore, as the cutaneous drug delivery rate of formulations is generally related to the concentration (activity) gradient of the drug towards the skin (provided that the affinity to the vehicle does not increase proportionally), the solubility potential of microemulsions may be an important factor in increasing skin absorption of drugs.
https://link.springer.com/article/10.1007/s11095-011-0404-y
Mar 25, 2011 · We aimed to investigate the influence of microemulsion nanoscale organization as either oil-in-water droplets, water-in-oil droplets, or bicontinuous structures on skin delivery of drugs assisted by microemulsions.Author: Wafa Naoui, Marie-Alexandrine Bolzinger, Bernard Fenet, Jocelyne Pelletier, Jean-Pierre Valour, Rafi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160947/
The changing IPM content showed greater influence on TMP skin flux, which was no more than 0.18 μg/cm 2 /h, when IMP content was <9% (w/w). Thus, the improvement in TMP solubility as well as the skin permeation enhancement effect of microemulsion components contributed mainly to transdermal delivery facilitation.Author: Ji-Hui Zhao, Li Ji, Hui Wang, Zhi-Qiang Chen, Yong-Tai Zhang, Ying Liu, Nian-Ping Feng
https://biomeddermatol.biomedcentral.com/articles/10.1186/s41702-020-0058-7
Transdermal delivery systems have been intensively studied over the past 2 decades, with the focus on overcoming the skin barrier for more effective application of pharmaceutical and cosmetic products. Although the cosmeceutical industry has made a substantial progress in the development and incorporation of new and effective actives in their products, the barrier function of the skin remains ...
https://www.semanticscholar.org/paper/LINKER-BASED-LECITHIN-MICROEMULSIONS-AS-TRANSDERMAL-Yuan/2d50f7ad012fbf520479054a804053344a29ab82
The interest in microemulsions as transdermal delivery systems have been motivated by their large surface area for mass transfer, their high solubilization capacity of hydrophobic actives, and their ability to improve skin penetration. Lecithins (mixtures of phospholipids similar to those find in the skin) have been proposed as ideal surfactants in microemulsions due to their skin ...
https://www.deepdyve.com/lp/elsevier/influence-of-microemulsions-on-cutaneous-drug-delivery-ZGntLSHyQC
Nov 01, 2002 · Influence of microemulsions on cutaneous drug delivery Microemulsion formulations have been shown to be superior for both transdermal and dermal delivery of particularly lipophilic compounds, but also hydrophilic compounds appear to benefit from application in microemulsions compared to conventional vehicles, like hydrogels, emulsions and liposomes.
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