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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392980/
The promise of cancer gene therapeutics is hampered by difficulties in the in vivo delivery to the targeted tumor cells, and systemic delivery remains to be the biggest challenge to be overcome. Here, we concentrate on systemic in vivo gene delivery for cancer therapy using nonviral vectors. In this review, we summarize the existing delivery barriers together with the requirements and ...Author: Yuan Zhang, Andrew Satterlee, Leaf Huang
http://www.biologydiscussion.com/gene/therapy/gene-therapy-ex-vivo-and-in-vivo-gene-therapy-with-diagram/9969
II. In vivo gene therapy: The direct delivery of genes into the cells of a particular tissue is referred to as in vivo gene therapy. Type # I. Ex Vivo Gene Therapy: The ex vivo gene therapy can be applied to only selected tissues (e.g., bone marrow) whose cells can be cultured in the laboratory.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC224587/
Although modification of the virion surface enhanced the efficiency of gene transduction into various cultured cell lines, in vivo gene delivery with recombinant baculoviruses is still unsatisfactory. One obstacle is the inactivation of baculovirus by serum complement (11, 35).Author: Hideki Tani, Chang Kwang Limn, Chan Choo Yap, Masayoshi Onishi, Masami Nozaki, Yoshitake Nishimune, ...
https://www.thermofisher.com/us/en/home/references/gibco-cell-culture-basics/transfection-basics/gene-delivery-technologies.html
Viral delivery: Highest efficiency amongst gene delivery methods (80–90% transduction efficiency in primary cells) Works well with difficult to transfect cell types; Can be used for in vivo delivery of nucleic acids; Can be used for making stable cell lines (retroviral …
https://www.pnas.org/content/102/32/11539
Aug 09, 2005 · Therefore, in vivo gene delivery is an area of considerable interest where genetic materials (e.g., DNA, RNA, and oligonucleotides) could be used to inhibit undesirable gene expression or to synthesize therapeutic proteins (4, 5). Given the potential of gene transfer as a therapeutic tool, the application of nanotechnology in the development of ...Author: Dhruba J. Bharali, Ilona Klejbor, Ewa K. Stachowiak, Purnendu Dutta, Indrajit Roy, Navjot Kaur, Earl...
https://www.nature.com/articles/gt2010105
Aug 12, 2010 · In vivo cardiac gene delivery follows a Poisson distribution. The intensity of cellular enhanced green fluorescence protein (eGFP) fluorescence in heart …Author: Konkal-Matt R. Prasad, Yaqin Xu, Zequan Yang, Scott T. Acton, Brent A French
https://www.nature.com/articles/s41434-019-0117-0
Jan 03, 2020 · The particle size of a PEG-peptide DNA nanoparticle is a key determinant of biodistribution following i.v. dosing. DNA nanoparticles of <100 …Author: Basil Mathew, Raghu Ramanathan, Nathan A. Delvaux, Jacob Poliskey, Kevin G. Rice
https://science.sciencemag.org/content/272/5259/263
Apr 12, 1996 · Additionally, the HIV vector could mediate stable in vivo gene transfer into terminally differentiated neurons. The ability of HIV-based viral vectors to deliver genes in vivo into nondividing cells could increase the applicability of retroviral vectors in human gene therapy.Author: Luigi Naldini, Ulrike Blömer, Philippe Gallay, Daniel Ory, Richard Mulligan, Fred H. Gage, Inder M. ...
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