We have collected information about In Vivo Cellular Delivery Of Sirna for you. Follow the links to find out details on In Vivo Cellular Delivery Of Sirna.
https://www.cell.com/molecular-therapy-family/nucleic-acids/pdf/S2162-2531(16)30083-X.pdf
siRNA and goes on to focus on recent advances in their peptide-mediated cell and in vivo delivery and how peptide use has influenced drug development. The review discusses the challenges associated with understanding the physiologi-cal and toxicological aspects of peptide-mediated delivery.
https://www.thermofisher.com/us/en/home/references/ambion-tech-support/rnai-sirna/tech-notes/getting-started-with-rnai-in-vivo.html
Technology exploiting this phenomenon may be used for functional genomics and target validation, and is being developed for therapeutic purposes. Because of its potency, siRNA has rapidly become the most widely used trigger for inducing gene knockdown in cultured mammalian cells. siRNA delivery in vivo is a more challenging task.
https://www.sciencedirect.com/science/article/pii/S0168365918300774
Upon cellular internalization and trafficking to acidic endosomes, the hydrophobic block switches to hydrophilic and exposes a membrane-lytic peptide, melittin . Plasmid DNA delivered by the polymer, named VIPER (virus-inspired polymer for endosomal release), avoids endosomal entrapment, resulting in efficient delivery in vitro and in vivo.Author: Daniel P. Feldmann, Yilong Cheng, Rima Kandil, Yuran Xie, Mariam Mohammadi, Hartmann Harz, Akhil Sha...
https://www.nature.com/articles/nprot.2012.131
Nov 15, 2012 · Here we show how exosomes derived from cultured cells can be harnessed for delivery of siRNA in vitro and in vivo. This protocol first describes the generation of targeted exosomes through ...Author: Samir El-Andaloussi, Samir El-Andaloussi, Yi Lee, Samira Lakhal-Littleton, Jinghuan Li, Yiqi Seow, C...
https://www.ncbi.nlm.nih.gov/pubmed/19075737
1. Curr Pharm Des. 2008;14(34):3603-19. Cellular delivery in vivo of siRNA-based therapeutics. Aigner A(1). Author information: (1)Department of Pharmacology and Toxicology, Philipps-University, School of Medicine, Karl-von-Frisch-Strasse 1, D - 35032 Marburg, Germany. [email protected] RNAi interference (RNAi) is an almost standard method for the knockdown of any target gene of ...Author: A. Aigner
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977003/
Jun 11, 2010 · Under in vivo conditions, siRNA and shRNA were equally effective in luciferase knockdown from 3 h to 3 days, although shRNA was significantly more potent on a molar basis . From the standpoint of transfection efficiency and delivery, siRNA poses advantages over shRNA.Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
https://www.ingentaconnect.com/contentone/ben/cpd/2008/00000014/00000034/art00002
RNAi is mediated by small interfering RNAs (siRNA), and thus siRNA delivery in vivo is of critical importance for its implementation. Due to the instability and physicochemical properties of siRNAs, the development of strategies and formulations for siRNA protection, cellular uptake, correct intracellular localization and endosomal release, in ...
https://www.cell.com/molecular-therapy-family/nucleic-acids/pdf/S2162-2531(19)30207-0.pdf
However, effective delivery remains a challenge, and presently no published research reports significant siRNA delivery to an intact corneal epithelium.11,28 In addition to overcoming pre-corneal tear film turnover and the other protective mechanisms described, it is necessary to promote cellular uptake of siRNA through the cellular membranes ...
https://www.biosyn.com/tew/In-vivo-delivery-of-lipophilic-siRNA.aspx
Covalent siRNA cholesterol conjugates are known to increase import into cellular where they induce RNAi resulting in the silencing of endogenous genes in vivo. Wolfram et al. in 2007 reported the preparation of a variety of lipophilic carrier molecules useful for optimized cell delivery. Long-chain fatty acid conjugates are helpful for cell ...
http://www.eurekaselect.com/68231
Keywords:RNA interference, small interfering RNA, RNAi, siRNA, gene targeting in vivo, polyethylenimine, in vivo siRNA delivery. Abstract: RNAi interference (RNAi) is an almost standard method for the knockdown of any target gene of interest in vitro, exploring a naturally occurring catalytic mechanism. Beyond functional analyses, the ...Author: A. Aigner
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