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https://www.nature.com/articles/nm1486
Feb 25, 2007 · At present, reports of the in vivo imaging of siRNA in target tissues are limited to bioluminescence imaging of siRNA-mediated silencing 9,15. The assessment of siRNA delivery, however, is currently based only on ex vivo studies.Author: Zdravka Medarova, Wellington Pham, Christian Farrar, Victoria Petkova, Anna Moore
https://link.springer.com/protocol/10.1007/978-1-60327-547-7_5
Oct 13, 2008 · The fast developing field of RNA interference (RNAi) requires monitoring of small interfering RNA (siRNA) delivery to targeted organs and evaluating the efficiency of target gene silencing. The molecular imaging approach fits perfectly to fulfill these needs and provides information in a fast, reproducible, and noninvasive manner.Author: Anna Moore, Zdravka Medarova
https://www.researchgate.net/publication/24215343_Imaging_of_siRNA_Delivery_and_Silencing
The fast developing field of RNA interference (RNAi) requires monitoring of small interfering RNA (siRNA) delivery to targeted organs and evaluating the efficiency of target gene silencing.
https://www.ncbi.nlm.nih.gov/pubmed/17322898
With the increased potential of RNA interference (RNAi) as a therapeutic strategy, new noninvasive methods for detection of siRNA delivery and silencing are urgently needed. Here we describe the development of dual-purpose probes for in vivo transfer of siRNA and the simultaneous imaging of its accumulation in tumors by high-resolution magnetic resonance imaging (MRI) and near-infrared in …Author: Zdravka Medarova, Wellington Pham, Christian Farrar, Victoria Petkova, Anna Moore
https://www.researchgate.net/publication/6483262_In_vivo_imaging_of_siRNA_delivery_and_silencing_in_tumors
In vivo imaging of siRNA delivery and silencing in tumors Article (PDF Available) in Nature Medicine 13(3):372-7 · April 2007 with 183 Reads How we measure 'reads'
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832477/
The two strategies for imaging siRNA delivery are: labeling the siRNA itself (which may affect its function/specificity and RNAi efficiency) or labeling the siRNA carrier. The latter will not affect the efficacy of siRNA, but the imaging data represent localization of the carrier rather than the siRNA.Author: Hao Hong, Yin Zhang, Weibo Cai
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1331994/
Jan 12, 2006 · Using noninvasive bioluminescent imaging and a mathematical model of siRNA delivery and function, the effects of target-specific and treatment-specific parameters on siRNA-mediated gene silencing are monitored in cells stably expressing the firefly luciferase protein.Author: Derek W. Bartlett, Mark E. Davis
https://www.researchgate.net/publication/284670090_Targeted_Delivery_with_Imaging_Assessment_of_siRNA_Expressing_Nanocassettes_into_Cancer
In this study, multifunctional siRNA delivery nanoparticles are developed that combine imaging capability of nanoparticles with urokinase plasminogen activator receptor-targeted delivery of siRNA ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212614/
Therapeutic siRNA silencing in inflammatory monocytes. ... R.W., D. A. and M.N. designed experiments, developed siRNA delivery technology and in vivo imaging strategies and systems, and reviewed, analyzed and discussed data. MN and RW wrote the manuscript which was edited and approved by all co-authors. M.N. developed and supervised the project.Author: Florian Leuschner, Partha Dutta, Rostic Gorbatov, Tatiana I Novobrantseva, Jessica S Donahoe, Gabrie...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693358/
Intravaginal delivery of siRNA using biodegradable nanoparticles causes gene silencing throughout the reproductive tract of transgenic GFP mice To determine the onset and duration of gene silencing, we examined the time course of gene knockdown produced from lipoplex and nanoparticle delivery of siRNA …Author: Kim A. Woodrow, Yen Cu, Carmen J. Booth, Jennifer K. Saucier-Sawyer, Monica J. Wood, W. Mark Saltzma...
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