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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412368/
Hydrodynamic injection induces a transient irregularity in heart function and a rapid increase in vena cava pressure. We suspect that the hydrodynamic injection would result in changes in heart function and venous pressure because the injection volume required for efficient hepatic delivery is approximately equivalent to the total blood volume of a mouse. 1,2 To provide a quantitative ...Author: G Zhang, X Gao, YK Song, R Vollmer, DB Stolz, JZ Gasiorowski, DA Dean, D Liu
https://www.nature.com/articles/3302210
Jan 15, 2004 · Hydroporation as the mechanism of hydrodynamic delivery. ... Based on these data, we propose a model to explain the mechanism underlying hydrodynamic delivery to the hepatocytes.Author: G Zhang, X Gao, YK Song, R Vollmer, DB Stolz, JZ Gasiorowski, DA Dean, D Liu
https://www.ncbi.nlm.nih.gov/pubmed/14724673
Hydroporation as the mechanism of hydrodynamic delivery. Zhang G(1), Gao X, Song YK, Vollmer R, Stolz DB, Gasiorowski JZ, Dean DA, Liu D. Author information: (1)Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15261, USA.Author: G Zhang, X Gao, YK Song, R Vollmer, DB Stolz, JZ Gasiorowski, DA Dean, D Liu
https://www.researchgate.net/publication/8918091_Hydroporation_as_the_mechanism_of_hydrodynamic_delivery
Hydroporation as the mechanism of hydrodynamic delivery Article (PDF Available) in Gene Therapy 11(8):675-82 · May 2004 with 127 Reads How we measure 'reads'
https://www.sciencedirect.com/science/article/pii/S1525001616327198
Applications of hydrodynamic gene delivery in the functional analysis of regulatory elements include studies on promoter strength, 100, 101, 102 Epstein-Barr virus sequence, 9, 103 intron sequences, 104 CpG sequences, 67, 93, 105 bacterial backbone, 12, 106 the mechanism of transposon-mediated integration into chromosome, 13, 107, 108 and a real-time study of xenobiotics-induced gene ...Author: Takeshi Suda, Dexi Liu
https://www.researchgate.net/publication/241604674_812_Hydroporation_as_the_Mechanism_Accounting_for_Efficient_Gene_Transfer_by_Hydrodynamic_Delivery
Hydroporation as the Mechanism Accounting for Efficient Gene Transfer by Hydrodynamic Delivery Article (PDF Available) in Molecular Therapy 9 · May 2004 with 38 Reads How we measure 'reads'
https://pubs.acs.org/doi/pdf/10.1021/acsnano.9b07930
(D) Hydrodynamic cell deformation via (1) the spiral vortex at the cross-junction and (2) cell-wall collision at the T-junction(s) (scale bars: 20 and 30 μm for (1) and (2), respectively). (E) Schematic illustrating nanomaterial delivery into cell cytosols.
https://pubs.acs.org/doi/10.1021/acsnano.9b07930
Briefly, in this method, cells in the spiral vortex flow undergo an intrinsic hydrodynamic cell deformation–restoration process (we subsequently refer to this mechanism as “spiral hydroporation”), which opens the cell membrane, allowing rapid transport of exogenous nanomaterials into the cytosol.Author: GeoumYoung Kang, Daniel W. Carlson, Tae Ho Kang, Seungki Lee, Simon J. Haward, Inhee Choi, Amy Q. Sh...
http://europepmc.org/articles/PMC4412368
Apr 01, 2004 · Hydroporation as the mechanism of hydrodynamic delivery. G Zhang Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15261, USA.Author: Zhang G
https://www.sciencedirect.com/science/article/pii/S0065266005540045
At the cellular level, the mechanism of hydrodynamic delivery is the generation of pores in the plasma membrane, which allow substances that would otherwise be excluded to enter cells. The term “hydroporation” has been proposed to reflect the physical nature and the mechanism of hydrodynamic delivery (Zhang et al., 2004a).
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