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https://www.sciencedirect.com/science/article/pii/S2211383515001069
Insoluble drug delivery strategies: review of recent advances and business prospects. ... The hydrophobic nature of cavity enables entrapment of hydrophobic molecules of suitable size inside the cavity and hydrophilic surface of CD makes complex soluble in water. Apart from solubilization, cyclodextrins are also used for drug stabilization ...Author: Sandeep Kalepu, Vijaykumar Nekkanti
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768187/
Jan 10, 2018 · To confirm capability of PolyDots for intracellular drug delivery, cellular uptake of lyophilized and reconstituted, coumarin 6 dye-loaded PolyDots was examined. Two model glioma cell lines were employed, as glioma is a potential target for hydrophobic drug delivery (eg, vorinostat65).Author: Gauri M Nabar, Kalpesh D Mahajan, Mark A Calhoun, Anthony D Duong, Matthew S Souva, Jihong Xu, Cathe...
https://www.sciencedirect.com/science/article/pii/S0032386108000487
Hydrogels in drug delivery: Progress and challenges ... Hydrogel-based hydrophobic drug delivery is in many respects a more difficult problem given the inherent incompatibility of the hydrophilic hydrogel network and the hydrophobic drug. Thus, the problem of hydrophobic drug delivery is two-fold: how to load the hydrophobic drug into the gel ...Author: Todd R. Hoare, Daniel S. Kohane
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438887/
Polymers have played an integral role in the advancement of drug delivery technology by providing controlled release of therapeutic agents in constant doses over long periods, cyclic dosage, and tunable release of both hydrophilic and hydrophobic drugs. ...Author: William B. Liechty, David R. Kryscio, Brandon V. Slaughter, Nicholas A. Peppas
https://pubs.acs.org/doi/10.1021/acs.nanolett.7b04307
The targeted delivery of hydrophobic therapeutic drugs to tumors is one of the major challenges in drug development. The use of natural proteins as drug delivery vehicles holds great promise due to various functionalities of proteins. In the current study, we exploited a natural protein, GroEL, which possesses a double layer cage structure, as a hydrophobic drug container, which is switchable ...Author: Yi Yuan, Chong Du, Cuiji Sun, Jin Zhu, Shan Wu, Yinlong Zhang, Tianjiao Ji, Jianlin Lei, Yinmo Yang,...
https://www.researchgate.net/publication/334437690_Nanoemulsion_A_Review_on_Mechanisms_for_the_Transdermal_Delivery_of_Hydrophobic_and_Hydrophilic_Drugs
Nanoemulsion: A Review on Mechanisms for the Transdermal Delivery of Hydrophobic and Hydrophilic Drugs. ... make NE a very attractive approach for transdermal drug delivery. This review focuses on ...
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201908357
Jul 30, 2019 · Bifunctional amphiphilic peptides are designed to not only stabilize hydrophobic drug nanoparticles but also induce biosilicification at the nanodrug particle surface thus forming drug‐core silica–shell nanocomposites. This platform technology is highly versatile for encapsulating various hydrophobic cargos.Author: Guangze Yang, Yun Liu, Haofei Wang, Russell Wilson, Yue Hui, Lei Yu, David Wibowo, Cheng Zhang, Andr...
https://patents.google.com/patent/CA2439500A1/en
Compositions comprising microaggregates containing hydrophobic drugs, as well as methods for their production, are described. Suchmicroaggregates may include micelle structures or combinations thereof with liposomes, and constitute an effective delivery vehicle for a hydrophobic agent. Methods for microaggregate production include the use of preferred lipid compounds and processing conditions ...Author: Ronald Erwin Boch, Dev Mitra Ranji Singh, Iman Karmadi
https://patents.google.com/patent/US5430021A/en
A pharmaceutical preparation including a drug incorporated into hydrophobic particles comprised of long chain carboxylic acid or ester thereof or long chain alcohol, wherein the particles are incorporated into a unit dosage form and are individually coated with an enteric coating and/or the unit dosage form includes an enteric protective material.Author: Edward M. Rudnic, John A. McCarty, George W. Belenduik
https://pubs.acs.org/doi/10.1021/mp050010c
Chitosan-based polymer micelles have a splendid outlook for drug delivery owing to the interesting properties, abundance, and low cost of chitosan. A new method of preparation of water-soluble N-palmitoyl chitosan (PLCS) which can form micelles in water is developed in this paper. The preparation of PLCS was carried out by swollen chitosan coupling with palmitic anhydride in dimethyl sulfoxide ...Author: Gang-Biao Jiang, Daping Quan, Kairong Liao, Haihua Wang
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