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https://www.sciencedirect.com/science/article/pii/S0928098716305383
4. Applications of hydrazone linkages for pH-responsive drug delivery systems. It has been observed that, with very few exceptions, pH-responsive delivery systems have been main exploited to deliver anticancer drugs to the tumor site, where acidity is low compared to the normal physiological pH of …Author: Sandeep J. Sonawane, Rahul S. Kalhapure, Thirumala Govender
https://www.ncbi.nlm.nih.gov/pubmed/27979586/
Mar 01, 2017 · Hydrazone linkages in pH responsive drug delivery systems. Sonawane SJ(1), Kalhapure RS(2), Govender T(3). Author information: (1)Discipline of Pharmaceutical Sciences, School of Health Sciences, University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa.Author: Sandeep J. Sonawane, Rahul S. Kalhapure, Thirumala Govender
https://www.sciencedirect.com/science/article/abs/pii/S0928098716305383
Hydrazone linkages are significant synthons for numerous transformations and have gained importance in pharmaceutical sciences due to their various biological and clinical applications. These linkages have been employed in various drug delivery vehicles, such as linear polymers, star shaped polymers, dendrimers, micelles, liposomes and ...Author: Sandeep J. Sonawane, Rahul S. Kalhapure, Thirumala Govender
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787066/
In this study, the structure–activity relationship of amphiphilic block copolymer micelles as nanosized drug delivery system was revealed. Firstly, a biodegradable triblock polymers PEG-DiHyd-PLA containing hydrazone bond was synthesized through the ring-opening polymerization.Author: Peilan Qi, Xiaohe Wu, Lei Liu, Huimin Yu, Shiyong Song
https://www.frontiersin.org/articles/10.3389/fphar.2018.00012/full
Jan 23, 2018 · In this study, the structure–activity relationship of amphiphilic block copolymer micelles as nanosized drug delivery system was revealed. Firstly, a biodegradable triblock polymers PEG-DiHyd-PLA containing hydrazone bond was synthesized through the ring-opening polymerization. In this method, PEG-DiHyd-Phenol was used as the initiator and L-lactide as the monomer. Then, the …Author: Peilan Qi, Xiaohe Wu, Lei Liu, Huimin Yu, Shiyong Song
https://www.researchgate.net/publication/332323870_ADVANCES_OF_HYDRAZONE_LINKER_IN_POLYMERIC_DRUG_DELIVERY
Request PDF ADVANCES OF HYDRAZONE LINKER IN POLYMERIC DRUG DELIVERY Polymeric drug delivery vehicles are known for the controlled release of the drug…
https://www.researchgate.net/publication/311705947_Hydrazone_linkages_in_pH_responsive_drug_delivery_systems
The materials used for fabricating pH-responsive drug delivery systems include a specific chemical functionality in their structure that can respond to changes in the pH of the surrounding ...
https://pubs.acs.org/doi/10.1021/acs.biomac.9b00020
Precise local delivery of chemotherapeutic agents employing an injectable depot could be a promising approach to achieve spatiotemporal control over the drug release along with minimizing the challenges associated with the systemic delivery of chemotherapeutic agents.Author: Peeyush Kumar Sharma, Yashveer Singh
https://pubs.rsc.org/en/content/articlelanding/2015/ra/c5ra02097b
We report that the polymer residue of hydrazone-containing pH-responsive polymeric conjugate micelles could induce considerable cytotoxicity in a model cell line (HeLa). However, there was no significant difference between the cytotoxicity of the residue of the model drug …Author: Yu Zhang, Min Gao, Chao Chen, Zheng Wang, Yanjun Zhao
https://pubs.rsc.org/en/content/articlepdf/2020/sc/c9sc05321b
cells can improve the precision of controlled drug release, thus enhancing the efficiency of drug delivery. Here, we report on a photochromic nanoparticle system (LSNP), assembled from fluorescent bistable hydrazone photoswitch-modified amphiphilic copolymers. The intrinsic emission of the hydrazoneAuthor: Xing Guo, Baihao Shao, Shaobing Zhou, Ivan Aprahamian, Zi Chen
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