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https://www.sciencedirect.com/science/article/pii/S0939641105000731
Normal human bronchial epithelial cell culture can provide a mixed ciliated and goblet cell culture model of the airway, which has been reported to provide a permeability barrier which would be suitable for drug transport studies [32], [33], [34].Author: Ben Forbes, Carsten Ehrhardt, Carsten Ehrhardt
https://www.sciencedirect.com/science/article/abs/pii/S0939641105000731
Constraints on experimentation using animals have promoted the use of human respiratory epithelial cell cultures to model the absorption barrier of the lung; with two airway cell lines, 16HBE14o- and Calu-3, and primary cultured human alveolar type I-like cells (hAEpC) gaining prominence.Author: Ben Forbes, Carsten Ehrhardt, Carsten Ehrhardt
https://www.researchgate.net/publication/7803542_Human_respiratory_epithelial_cell_culture_for_drug_delivery_applications
Constraints on experimentation using animals have promoted the use of human respiratory epithelial cell cultures to model the absorption barrier of the lung; with two airway cell lines, 16HBE14o ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951077/
Jun 27, 2010 · In summary, Calu-3 air-liquid interface cell culture in an environmental chamber is a sensitive and efficient model to simulate clinical situations and for screening respiratory drug applications. This cell model is useful for the study of human respiratory diseases, airway injury related to oxygen toxicity, and positive mechanical ventilation, and the evaluation of novel therapies.Author: Yan Zhu, Aaron Chidekel, Aaron Chidekel, Thomas H. Shaffer, Thomas H. Shaffer, Thomas H. Shaffer
https://link.springer.com/protocol/10.1007/978-1-61779-367-7_3
Oct 07, 2011 · However, the increasing interest of aerosol administration of medicines to the respiratory system requires the development and use of representative in vitro models. Thereby, human alveolar epithelial cells (hAEpC) are a suitable test system allowing standardized toxicity and transport studies for newly developed compounds and delivery systems.Author: Nicole Daum, Anna Kuehn, Stephanie Hein, Ulrich F. Schaefer, Hanno Huwer, Claus-Michael Lehr
https://link.springer.com/article/10.1007%2Fs11095-006-0255-0
Jun 21, 2006 · The aim of this study was to compare the effect of liquid-covered culture (LCC) and air-interfaced culture (AIC) on Calu-3 cell layer morphology and permeability, thus assessing the fitness of these culture systems as models of airway epithelium barrier function. Cell layers were grown on 0.33 cm2 Transwell polyester cell culture supports.Author: Christopher I. Grainger, Leona L. Greenwell, David J. Lockley, Gary P. Martin, Ben Forbes
https://www.mattek.com/products/epiairway/
The EpiAirway 3D human tissue model is routinely utilized for a range of applications including safety & risk assessment, anti-viral research, inflammation & fibrosis and drug delivery. Simple protocols and the evaluation of early cellular endpoints allow scientists to acquire data in days, not weeks or months.
https://www.researchgate.net/publication/257808630_Application_of_biopharmaceutics_classification_system_BCS_in_drug_transport_studies_across_human_respiratory_epithelial_cell_monolayers
Transport studies of model drugs were conducted across the human nasal epithelial (HNE) and normal human bronchial epithelial (NHBE) cell monolayers cultured by air–liquid interface method.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769873/
Technosphere particles have high internal porosity and high surface area for the adsorption of proteins or other drug substances. Technosphere Insulin powder consists of insulin that is adsorbed to Technosphere particles with a size range appropriate for delivery of drugs to the deep lung.Author: Robert Angelo, Kathleen Rousseau, Marshall Grant, Andrea Leone-Bay, Peter Richardson
https://en.wikipedia.org/wiki/Calu-3
The cells have been used in studies of pulmonary drug delivery, demonstrating a capacity to intake low molecular weight substances. Calu-3 cells have served as respiratory models for air intake and lung injury due to their responsiveness to foreign substances.
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