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https://www.sciencedirect.com/science/article/pii/S0169409X01001120
Jun 11, 2001 · Hydroxypropyl methylcellulose (HPMC) is the most important hydrophilic carrier material used for the preparation of oral controlled drug delivery systems , . One of its most important characteristics is the high swellability, which has a significant effect on the release kinetics of an incorporated drug.Author: J. Siepmann, Nicholas Peppas
https://www.sciencedirect.com/topics/chemistry/hydroxypropyl-methylcellulose
HPMC is hydrophilic (water soluble), a biodegradable, and biocompatible polymer having a wide range of applications in drug delivery, dyes and paints, cosmetics, adhesives, coatings, agriculture, and textiles [174–176]. HPMC is also soluble in polar organic solvents, making it possible to use both aqueous and nonaqueous solvents.
https://onlinelibrary.wiley.com/doi/pdf/10.1211/0022357055957
The use of hypromellose in oral drug delivery Chi L. Li, Luigi G. Martini, James L. Ford and Matthew Roberts Abstract Hypromellose, formerly known as hydroxypropylmethylcellulose (HPMC), is by far the most com-monly employed cellulose ether used in the fabrication of …Author: Chi L. Li, Luigi G. Martini, James L. Ford, Matthew Roberts
https://link.springer.com/article/10.1023/A:1018914301328
The purpose of this study was to investigate the drug release mechanisms from hydroxypropyl methylcellulose (HPMC)-matrices, and to develop a new model for quantitative predictions of controlled drug delivery.Author: J. Siepmann, H. Kranz, R. Bodmeier, N. A. Peppas
http://www.davidpublisher.org/Public/uploads/Contribute/579b06d2b5dab.pdf
6. Use of HPMC in Different Drug Delivery Systems 6.1 Systems with Eroding or Soluble Barrier Coatings HPMC can be well used in the preparations of drug delivery systems with eroding or soluble barrier coatings. These types of delivery systems contain reservoir devices which are coated with a …
https://www.imedpub.com/articles/hydroxypropyl-methylcellulose-in-drug-delivery.pdf
Then targeted controlled delivery of drug with physical stable gel will be obtained. Gaudana et al. have shown use of HPMC in currently available different hydrogel based drug delivery system 18 (Gaudana R., et al) such as Hydrogel 1:Gatifloxacin is drug and Alginate, HPMC are used as polymer.
https://www.researchgate.net/publication/7840944_The_use_of_Hypromellose_in_oral_drug_delivery
Hypromellose, formerly known as hydroxypropylmethylcellulose (HPMC), is by far the most commonly employed cellulose ether used in the fabrication of hydrophilic matrices. Hypromellose …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374565/
In fact, matrix system has proven popular among the oral controlled drug delivery technologies because of their simplicity, ease in manufacturing, high level of reproducibility, stability of the raw materials and dosage form and ease of scale up and process validation[4–6]. In the current study, hydroxypropyl methyl cellulose (HPMC) is selected as a model hydrophilic polymer to prepare a controlled release …
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