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https://www.meddeviceonline.com/doc/critical-considerations-for-high-viscosity-high-volume-drug-delivery-devices-0001
In particular are issues of high viscosity and/or high volume (HV/HV) associated with biologics. Since biologics cannot be taken orally, as the conditions within the stomach denature the molecules, biologics must therefore be delivered via an injection.Location: 1201 Hanley Road Hudson, WI 54016 US
https://www.ondrugdelivery.com/injecting-high-volume-high-viscosity-drugs/
For higher viscosity drug preparations, SHL’s Bertha ® (Figure 1) provides the safe and reliable delivery of up to 60 centipoise. Bertha ® is a disposable, fixed-dose autoinjector that is compatible with either a 1.0 mL or 2.25 mL prefilled syringe.
https://www.ondrugdelivery.com/patient-tolerability-with-high-viscosity-large-volume-subcutaneous-infusions/
Characteristics of the drug that impact patient tolerability of high-viscosity, large-volume SC infusion must be considered. Volume and Viscosity. Typically, pharmaceutical companies have had the mindset to pursue high-concentration (high-viscosity) and low-volume formulations based on limitations with previously available delivery systems.
https://enableinjections.com/
Enable Injections develops on-body delivery devices that allow your patients to self-administer high volume (up to 50 ml) and/or high viscosity therapeutics.
https://www.greystoneassociates.org/drug-delivery/injectable-drug-delivery/handheld-devices-for-injecting-high-viscosity-drugs/
Home / Drug Delivery / Injectable Drug Delivery / Handheld Devices for Injecting High Viscosity Drugs Handheld Devices for Injecting High Viscosity Drugs Handheld Devices for Injecting High Viscosity Drugs • September 2018 • No. HVJ525K • US $3,850
https://link.springer.com/article/10.1208%2Fs12249-018-0963-x
Feb 20, 2018 · The high viscosity of the formulation affects both syringeability and formulation performance during injection, necessitating more force with an acceptable needle gauge and time needed. Presently, intravenous, intramuscular, and more convenient subcutaneous route is the most frequently used methods of delivering biologicals.Author: Qiangnan Zhang, Mona A. Fassihi, Reza Fassihi
https://biopharmadealmakers.nature.com/users/13785-portal-instruments/posts/17597-needle-free-solving-challenges-with-viscous-biologic-self-injections
Jun 06, 2017 · However, challenges exist with the delivery of biologics: to be effective, these biologics often need to be delivered at high doses, but regulatory bodies impose limits on …Author: Portal Instruments
http://www.pharmtech.com/injecting-highly-viscous-drugs
Nov 02, 2014 · The high mg per mL concentrations of these macromolecule drugs result in high enough viscosities of the injectable product to cause problems for device designers, manufacturers, primary container suppliers, and patients.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646585/
Nov 11, 2015 · Specifically, less pain was associated with high viscosity (VAS =12.6 mm) than medium (VAS =16.6 mm) or low (VAS =22.1 mm) viscosities, with a significant difference between high and low viscosities (P=0.0002).Author: Cecile Berteau, Orchidée Filipe-Santos, Tao Wang, Humberto E Rojas, Corinne Granger, Florence Schwar...
High Volume, High Viscosity, Modular Wearable Injector and Pump Technology. ... The vision of Large Volume Wearable Drug Delivery becomes reality with the Weibel CDS Wearable Injector Platform. safer, easier and faster drug delivery - tested and fit for purpose ... Weibel CDS AG Mühlenstrasse 26 CH-8200 Schaffhausen +41 71 351 73 21
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