Hepatocyte Oxygen Delivery

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Zonal liver cell heterogeneity: effects of oxygen on ...

    https://lmrt.mit.edu/sites/default/files/Bhatia1996_JCellEng.pdf
    Zonal liver cell heterogeneity: effects of oxygen on metabolic ... surface on ambient oxygen tension and hepatocyte density in a mono-layer configuration. This model has been extended to ... oxygen partial pressures of 7.4, 37, 51, 74, 110 and 154 mm Hg discussed in the following long-term culture experiment correspond to oxygen partial ...

Oxygen Uptake Rates and Liver-Specific Functions of ...

    https://web.njit.edu/~cho/Cho_07_BB.pdf
    Oxygen Uptake Rates and Liver-Specific Functions of Hepatocyte and 3T3 Fibroblast Co-Cultures Cheul H. Cho, Jaesung Park, Deepak Nagrath, Arno W. Tilles, Franc¸ois Berthiaume, ... and adequate oxygen delivery to the hepatocytes is ... Oxygen Uptake Rates of Hepatocyte and Fibroblast Co-Cultures 189 Biotechnology and Bioengineering. DOI 10 ...

Enhanced Oxygen Delivery Reverses Anaerobic ... - DeepDyve

    https://www.deepdyve.com/lp/elsevier/enhanced-oxygen-delivery-reverses-anaerobic-metabolic-states-in-HhJHuVcpIY
    Read "Enhanced Oxygen Delivery Reverses Anaerobic Metabolic States in Prolonged Sandwich Rat Hepatocyte Culture, Experimental Cell Research" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.

Improved Oxygen Delivery to Hepatic Hollow Fiber Bioreactors

    https://curate.nd.edu/show/bn999595x0b
    Oxygen provision to hepatocytes (and other types of cells) maintained within the extracapillary space of a hollow fiber (HF) bioreactor is believed to be transport limited because of the low solubility of oxygen in aqueous media and the high cellular oxygen demand. This …Author: Jason E Gordon

Oxygen-mediated enhancement of primary hepatocyte ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747185/
    Sep 15, 2009 · Reducing hepatocyte density to the point where oxygen is no longer limiting can have a similar effect to increasing oxygen tension. The Cho et al. demonstration of elevated oxygen uptake rates and enhanced synthetic function in low density cultures of rat hepatocytes supports this assertion . However, homotypic interactions are important in the ...Author: Srivatsan Kidambi, Rubin S. Yarmush, Eric Novik, Piyun Chao, Martin L. Yarmush, Yaakov Nahmias, Yaak...

Enhanced Oxygen Delivery to Primary Hepatocytes within a ...

    https://www.researchgate.net/publication/5750928_Enhanced_Oxygen_Delivery_to_Primary_Hepatocytes_within_a_Hollow_Fiber_Bioreactor_Facilitated_via_Hemoglobin-Based_Oxygen_Carriers
    Enhanced Oxygen Delivery to Primary Hepatocytes within a Hollow Fiber Bioreactor Facilitated via Hemoglobin-Based Oxygen Carriers ... rate and outlet fluid pressure increases oxygen delivery to ...

(10b) Improved Oxygen Delivery to Hepatocytes Maintained ...

    https://www.aiche.org/conferences/aiche-annual-meeting/2005/proceeding/paper/10b-improved-oxygen-delivery-hepatocytes-maintained-within-hollow-fiber-bioreactor-bovine-red-blood-0
    Oct 31, 2005 · Inadequate oxygen delivery to hepatocytes can reduce viability levels and hamper expression of differentiated function. This problem can potentially be alleviated via the addition of an oxygen carrier to a circulating bioreactor media feed stream.

Overexpressing kringle 1 domain of hepatocyte growth ...

    https://www.ncbi.nlm.nih.gov/pubmed/30471863
    Jan 01, 2019 · Kringle1 domain of hepatocyte growth factor (HGFK1) has anti-angiogenesis activity. Here, we established oxygen-induced retinopathy (OIR) model to study if using adeno-associated virus (AAV) as a delivery system to overexpression HGFK1 in retinal cells could benefit retinal neovascularization.Author: Peng Sun, Zheli Liu

Improved Oxygenation Dramatically Alters Metabolism and ...

    https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/hep4.1140
    oxygen delivery to hepatocytes by shaking prevents hypoxic adaptive responses. Our results demonstrate that the shaken hepatocyte culture is a simple strategy to avoid activation of HIF signaling, aberrant glucose metabolism and triglyceride accumulation, and down-regulation of hepatocyte-enriched transcriptional fac-tors in primary hepatocyte ...Author: Eduardo H. Gilglioni, Jung Chin Chang, Suzanne Duijst, Simei Go, Aziza A. A. Adam, Ruurdtje Hoekstra...

Hyperbaric Oxygen Therapy in Liver Diseases

    http://www.medsci.org/v15p0782.htm
    Hyperbaric oxygen therapy protects the liver from apoptosis caused by ischemia-reperfusion injury in rats. Microsurgery. 2009;29:578-83 14. Chaves JC, Neto FS, Ikejiri AT, Bertoletto PR, Teruya R, Santos Simoes R. et al. Period of Hyperbaric Oxygen Delivery Leads to Different Degrees of Hepatic Ischemia/Reperfusion Injury in Rats.Author: Yun Sun, Yankai Wen, Chanjuan Shen, Yuanrun Zhu, Wendong You, Yuanyuan Meng, Lijuan Chen, Yiping Fen...

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