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http://www.jarcet.com/articles/Vol2Iss1/Hull.htm
In order for a drug to be a practical candidate for transdermal delivery, it must possess physicochemical properties that are associated with relatively high permeability. These properties include a low-molecular-weight (<1000) and adequate solubility in oil and water.
https://www.researchgate.net/publication/286303914_Heat-enhanced_transdermal_drug_delivery_A_survey_paper
Transdermal drug delivery has numerous advantages over traditional oral and intravenous delivery routes because there is avoidance of risks and inconveniences usually associated with the later [27].Author: Wade Hull
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581683/
In this study, a commonly administered transdermal NSAID, ketoprofen, was selected to prepare a heat-enhanced transdermal patch that contained the drug in an aqueous poloxamer 407 gel . Molecular insight into the mechanism by which heat improves ketoprofen release is provided, by using molecular dynamics (MD) simulations (25–29).Author: Daniel P. Otto, Melgardt M. de Villiers
https://www.researchgate.net/publication/233891958_The_Experimental_Evaluation_and_Molecular_Dynamics_Simulation_of_a_Heat-Enhanced_Transdermal_Delivery_System
The Experimental Evaluation and Molecular Dynamics Simulation of a Heat-Enhanced Transdermal Delivery System Article (PDF Available) in AAPS PharmSciTech 14(1) · December 2012 with 990 Reads
https://www.semanticscholar.org/paper/Modeling-and-design-of-transdermal-drug-delivery-an-Kim-Simon/18c83589fd96c1d2424b3ee070d080ee5fd8fbc4
Abstract Process modeling and design concepts were implemented to aid in the manufacturing of heat-enhanced transdermal drug-delivery systems. The simulated prototype consists of a corticosterone-loaded polymer patch applied to the skin and connected to a heating device in which an exothermic reaction occurs. To achieve a desired transdermal flux of 1.2 × 10 −5 mg/cm 2 h, this contribution ...
https://www.future-science.com/doi/10.4155/tde.14.66
Transdermal drug delivery systems (TDDS) pose several advantages and challenges as a dosage form. Amongst the advantages, localized or topical delivery is made possible, better patient compliance is ensured due to the ease of application, infrequent application requirements and the non-invasive administration of drugs compared with, for example, parenteral routes [].Author: Otto Dp, de Villiers Mm
https://www.sciencedirect.com/science/article/abs/pii/S0098135411000081
Process modeling and design concepts were implemented to aid in the manufacturing of heat-enhanced transdermal drug-delivery systems. The simulated prototype consists of a corticosterone-loaded polymer patch applied to the skin and connected to a heating device in which an exothermic reaction occurs.Author: Kwang Seok Kim, Laurent Simon
https://www.ncbi.nlm.nih.gov/pubmed/23229382
The experimental evaluation and molecular dynamics simulation of a heat-enhanced transdermal delivery system. Otto DP(1), de Villiers MM. Author information: (1)Catalysis and Synthesis Research Group, Chemical Resource Beneficiation Focus Area, Faculty of Natural Sciences, North-West University, Private Bag X6001, Potchefstroom, South Africa.Author: Daniel P. Otto, Melgardt M. de Villiers
https://link.springer.com/article/10.1208%2Fs12249-012-9900-6
Dec 11, 2012 · Chemical penetration enhancers and invasive methods that disturb the structural barrier function of the skin can be used to improve transdermal drug delivery. However, for suitable drugs, a fast-releasing transdermal delivery system can be produced by incorporating a heating source into a transdermal patch.Author: Daniel P. Otto, Melgardt M. de Villiers
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