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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620406/
Oct 26, 2015 · HDL as a Drug Delivery Vehicle. The use of lipoproteins and particularly HDL (Schouten et al., 1993) as drug delivery agents was first suggested over 30 years ago (Counsell and Pohland, 1982).Subsequently, Kader and Pater (2002) evaluated HDL particles as drug transporters. They have found that drugs incorporated into HDL were 2.5–23 times cytotoxic to cancer cells than the free (non ...Author: Andras G. Lacko, Nirupama A. Sabnis, Bhavani Nagarajan, Walter J. McConathy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196266/
Oct 15, 2018 · Drug delivery to malignant tumors is limited by several factors, including off-target toxicities and suboptimal benefits to cancer patient. Major research efforts have been directed toward developing novel technologies involving nanoparticles (NPs) to overcome these challenges.Author: Sangram Raut, Linda Mooberry, Nirupama Sabnis, Ashwini Garud, Akpedje Serena Dossou, Andras Lacko
https://www.unthsc.edu/graduate-school-of-biomedical-sciences/physiology-and-anatomy/physiology/lipoprotein-drug-delivery-research-laboratory/
Lipoprotein Drug Delivery Research Lab works at the interface of biochemistry, molecular biology, and material sciences. Our efforts are focused on understanding the cholesterol metabolism in cancer and use of reconstituted high-density lipoproteins (rHDL) to deliver drugs to cancer cells via HDL receptor SR-B1. Below are the 2 important aspects of rHDL nanoparticles 1. Non-leaky, Read More »
https://www.sciencedirect.com/science/article/pii/S0169409X16301405
High-density lipoprotein (HDL) is a comparatively dense and small lipoprotein that can carry lipids as a multifunctional aggregate in plasma. Several studies have shown that increasing the levels or improving the functionality of HDL is a promising target for treating a wide variety of diseases.Author: Zhong-Cheng Mo, Kun Ren, Xing Liu, Zhen-Li Tang, Guang-Hui Yi
https://www.medscape.com/viewarticle/561797
Nov 10, 2019 · Low-density lipoproteins have long been recognized as a viable nanocarrier for targeted delivery of drug and imaging agents. Many groups have published promising initial findings; however ...
https://markets.businessinsider.com/news/stocks/cerenis-to-present-new-data-validating-hdl-targeted-drug-delivery-in-the-field-of-oncology-and-immuno-oncology-at-the-30th-eortc-nci-aacr1-symposium-1027640012
Oct 22, 2018 · CERENIS to Present New Data Validating HDL Targeted Drug Delivery in the Field of Oncology and Immuno-Oncology at the 30th EORTC/NCI/AACR1 …
https://www.researchgate.net/publication/334371599_The_role_of_high-density_lipoproteins_in_antitumor_drug_delivery
The use of both native and synthetic HDL as drug delivery agents is compared to evaluate their respective potentials for commercial and clinical development. The current status and future ...
https://www.researchgate.net/profile/Andras_Lacko/publication/284029522_HDL_as_a_drug_and_nucleic_acid_delivery_vehicle/links/564e22b308ae1ef9296c5ae6.pdf?inViewer=0&pdfJsDownload=0&origin=publication_detail
drug delivery agents in cancer chemotherapy. The use of both native and synthetic HDL as drug delivery agents is compared to evaluate their respective potentials for
https://www.frontiersin.org/articles/10.3389/fphar.2015.00247/full
Oct 26, 2015 · HDL as a Drug Delivery Vehicle. The use of lipoproteins and particularly HDL (Schouten et al., 1993) as drug delivery agents was first suggested over 30 years ago (Counsell and Pohland, 1982).Subsequently, Kader and Pater (2002) evaluated HDL particles as drug transporters. They have found that drugs incorporated into HDL were 2.5–23 times cytotoxic to cancer cells than the free (non ...Author: Andras G. Lacko, Nirupama A. Sabnis, Bhavani Nagarajan, Walter J. McConathy
https://medcraveonline.com/JSRT/lipoproteins-as-drug-delivery-vehicles-for-cancer-and-tumor-therapeutics.html
Present article focuses on various lipoprotein based drug delivery vehicles used in cancer and tumor therapeutics. Starting from aqueous phase delivery through liposomes or unilamellar vesicles, biomimetic HDL nanoparticles, discoidal recombinant high-density lipoproteins (d-rHDLs) are favorably used to deliver anticancer agents. LDL based carrier vehicles are reconstituted in many ways i.e ...
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