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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033020/
Feb 06, 2011 · Growth factors differ from other oligo-/polypeptide molecules, such as insulin and hormones, in the mode of delivery and response elicited. Typically, growth factors do not act in an endocrine fashion; they exhibit short-range diffusion through the extracellular matrix and act locally owing to their short half-lives and slow diffusion.Author: Kangwon Lee, Eduardo A. Silva, David J. Mooney, David J. Mooney
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586795/
Biomaterial scaffolds have been extensively used to deliver growth factors to induce new bone formation. The pharmacokinetics of growth factor delivery has been a critical regulator of their clinical success. This review will focus on the surface interactions ...Author: William J. King, Paul H. Krebsbach
https://www.nature.com/articles/am2017171
Oct 06, 2017 · Taking these points into account, it is clear that further research is necessary regarding the programmable release of growth factor delivery and smart biomaterial design.Author: Zhenming Wang, Zhefeng Wang, William Weijia Lu, Wanxin Zhen, Dazhi Yang, Songlin Peng
https://www.sciencedirect.com/science/article/pii/S0169409X12001007
Growth factor delivery: How surface interactions modulate release in vitro and in vivo ... The pharmacokinetics of growth factor delivery has been a critical regulator of their clinical success. This review will focus on the surface interactions that control the non-covalent incorporation of growth factors into scaffolds and the mechanisms that ...Author: William J. King, Paul H. Krebsbach
https://pubs.acs.org/doi/10.1021/bm801103c
The controlled delivery of growth factors is a very challenging task because many different issues have to be addressed to develop the best suited system. A wide range of approaches have been employed for the controlled delivery of growth factors by hydrogels.Author: Amanda K. Andriola Silva, Cyrille Richard, Michel Bessodes, Daniel Scherman, Otto-Wilhelm Merten
https://www.sciencedirect.com/science/article/pii/S0168365919302846
Growth factors play a crucial role in tissue engineering by directing the fate of cells and allowing the formation of tissues. Understanding the key requirements for growth factor delivery can point the way towards novel tissue engineering platforms.Author: Lilith M. Caballero Aguilar, Lilith M. Caballero Aguilar, Saimon M. Silva, Saimon M. Silva, Simon E....
https://www.nature.com/articles/nbt1101-1029
PDGF delivery resulted in a small increase in maturity. In contrast, dual growth factor delivery resulted in a markedly different distribution, with a trend toward larger, mature blood vessels.Author: Thomas P. Richardson, Martin C. Peters, Alessandra B. Ennett, David J. Mooney
https://www.hindawi.com/journals/ijps/2012/174942/
6.3.2. Growth Factor Delivery from Microsphere-Based Scaffolds. Nano- and microspheres containing BMPs are rarely used in isolation for bone regeneration purposes. Usually they are immobilised within/on a matrix to form a composite scaffold containing microspheres, or they are fused together to form a microsphere scaffold.Author: Keith A. Blackwood, Nathalie Bock, Tim R. Dargaville, Maria Ann Woodruff
https://www.sbir.gov/sbirsearch/detail/89399
By comparison, other growth factor-based therapies for wound healing rely on application of pre-formed growth factor, which may be rapidly destroyed due to "hyperactive proteolytic activity"- excessive protein destruction-which is an important feature of many chronic wounds.
https://www.researchgate.net/publication/12431432_Growth_Factor_Delivery_for_Tissue_Engineering
Growth Factor Delivery for Tissue Engineering. ... [36][37][38] However, a growth factor cannot always maintain its bioactivity when it is directly injected into the body, because of its short ...
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