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https://www.nature.com/articles/s41467-018-03705-y
Apr 12, 2018 · Targeted delivery approaches for cancer therapeutics have shown a steep rise over the past few decades. However, compared to the plethora of successful pre-clinical studies, only 15 passively targeted nanocarriers (NCs) have been approved for clinical use and none of the actively targeted NCs have advanced past clinical trials.Author: Daniel Rosenblum, Nitin Joshi, Nitin Joshi, Wei Tao, Jeffrey M. Karp, Jeffrey M. Karp, Dan Peer
https://sbir.cancer.gov/funding/contracts/pastcontracts/327
Nov 25, 2013 · The focus of this topic is on the reformulation of small-molecule chemotherapeutic agents. The proposed drug-delivery platform must yield a significant improvement in properties with respect to the free drug in order to enable the re-evaluation of the chemotherapeutic drug as a potential therapy for cancer treatment.
https://grants.nih.gov/grants/guide/pa-files/PAR-18-895.html
This Funding Opportunity Announcement (FOA) will support non-clinical product development for innovative CNS-targeted drug delivery strategies capable of suppressing or eradicating HIV in the CNS. The research activities must be guided by critical assessments of both efficacy in the CNS and neurotoxicity to ensure that enhanced drug concentrations in the CNS compartments do not …
https://www.ncbi.nlm.nih.gov/pubmed/22558072/
Targeted delivery of chemotherapy agents using a liver cancer-specific aptamer. Meng L(1), Yang L, Zhao X, Zhang L, Zhu H, Liu C, Tan W.Author: Ling Meng, Liu Yang, Xiangxuan Zhao, Lucy Zhang, Haizhen Zhu, Chen Liu, Weihong Tan
https://www.nature.com/articles/nmat2992
Apr 17, 2011 · Encapsulation of drugs within nanocarriers that selectively target malignant cells promises to mitigate side effects of conventional chemotherapy and to enable delivery of the unique drug ...Author: Carlee E. Ashley, Carlee E. Ashley, Eric C. Carnes, Genevieve K. Phillips, David P Padilla, Paul N. ...
http://grantome.com/grant/NSF/CBET-0753109
Drugs delivered by these cancer nuclear-targeted carriers had much high efficiency in killing cancer cells. Thus, the nuclear drug delivery developed in this project is a new drug delivery approach to effectively overcoming cancer drug resistance, a major cause of cancer treatment failure, and provides a new and effective therapy for clinical treatment of cancer.
https://www.sciencedirect.com/science/article/pii/S014296121300183X
In this study, a rational strategy was employed to take advantage of a combination of both TMSP and folate to create a more selective and efficient drug delivery system to cancer cells. The schematic of the dual-modified nanostructured lipid carrier (NLC) system modified with TMSP and folate is …Author: Wei Gao, Bai Xiang, Ting-Ting Meng, Feng Liu, Xian-Rong Qi
https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/chemotherapy/how-chemotherapy-drugs-work.html
The protein or receptor is precisely targeted by the drug, so normal cells are not affected by the drugs. This is different than how traditional chemotherapy drugs work. Targeted drugs can be used as the main treatment for a cancer, or they may be used after treatment to keep the cancer under control or keep it from coming back.
https://www.cancer.gov/about-cancer/treatment/types/targeted-therapies/targeted-therapies-fact-sheet
Targeted therapies are often cytostatic (that is, they block tumor cell proliferation ), whereas standard chemotherapy agents are cytotoxic (that is, they kill tumor cells). Targeted therapies are currently the focus of much anticancer drug development. They are a cornerstone of precision medicine,...
https://www.nih.gov/news-events/nih-research-matters/chemotherapy-using-nanoparticles
A new drug delivery technique may hold promise for more efficient cancer therapies. The technique involves storing a cancer drug inside tiny objects called nanoparticles. Using this method, researchers were able to shrink tumors in mice while using smaller doses of the drug to reduce harmful side effects.
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