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https://www.sciencedirect.com/science/article/pii/S1525001616306967
Gold nanoparticles provide an attractive and applicable scaffold for delivery of nucleic acids. In this review, we focus on the use of covalent and noncovalent gold nanoparticle conjugates for applications in gene delivery and RNA-interference technologies.Author: Ya Ding, Ya Ding, Ziwen Jiang, Krishnendu Saha, Chang Soo Kim, Sung Tae Kim, Ryan F Landis, Vincent ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490019/
Nov 05, 2012 · SiRNA therefore requires a greater number of vehicles per molecule, or a vehicle with a greater amount of cationic character. Both cases potentially lead to greater toxicity issues. We report here the use of gold nanoparticles featuring dendritic polyethylenimine-like ligands to generate a supramolecular siRNA delivery vehicle featuring high knockdown efficiency and low toxicity.Author: Sung Tae Kim, Apiwat Chompoosor, Yi-Cheun Yeh, Sarit S. Agasti, David J. Solfiell, Vincent M. Rotell...
https://onlinelibrary.wiley.com/doi/full/10.1002/smll.201201141
Dendronized gold nanoparticles (AuNPs) are effective nanocarriers for small interfering RNA (siRNA) delivery. Electrostatic condension of these AuNPs with …Author: Sung Tae Kim, Apiwat Chompoosor, Yi-Cheun Yeh, Sarit S. Agasti, David J. Solfiell, Vincent M. Rotell...
https://pubs.acs.org/doi/abs/10.1021/nl9003865
Here, we demonstrate the manufacture of uniform nanoparticles with the deposition of siRNA on gold in a layer-by-layer approach, and we further report on the cellular delivery and siRNA activity as functions of surface properties.Author: Asmaa Elbakry, Alaa Zaky, Renate Liebl, Reinhard Rachel, Achim Goepferich, Miriam Breunig
https://www.sciencedirect.com/topics/chemistry/gold-nanoparticle
14.4.1.2 Delivery of siRNA/DNA. Gold nanoparticles are considered to be an efficient system for delivery of either DNA or RNA for gene silencing and consequently for therapeutic purposes. Mirkin et al. demonstrated that a dense layer of ssDNA molecules can coat the surface of citrate stabilized spherical nanoparticles via thiol linkers and hence can be exploited for gene silencing.
https://pubs.rsc.org/en/content/articlelanding/2020/tb/c9tb02899d
Controlling and detecting cell differentiation in human mesenchymal stem cells (hMSCs) for regenerative medicine remain challenging at present. Here, we developed multifunctional gold nanoparticles (AuNPs) to control and detect osteogenic differentiation in human mesenchymal stem cells (hMSCs) in real-time. The pol Journal of Materials Chemistry B HOT PapersAuthor: Jinming Li, Qian Wu, Kaipeng Wang, Xichao Wang, Guohai Liang
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)30696-7
Jun 01, 2014 · Gold nanoparticles provide an attractive and applicable scaffold for delivery of nucleic acids. In this review, we focus on the use of covalent and noncovalent gold nanoparticle conjugates for applications in gene delivery and RNA-interference technologies.Author: Ya Ding, Ya Ding, Ziwen Jiang, Krishnendu Saha, Chang Soo Kim, Sung Tae Kim, Ryan F Landis, Vincent ...
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