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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058726/
The ophthalmic drug delivery is a challenge in the clinical treatment of ocular diseases. The traditional drug administration usually shows apparent limitations, such as the low bioavailability from the reason of low penetration of the cornea and the short survival time of drug in the eyes.Author: Cong Li, Rui Chen, Mengzhen Xu, Jiyan Qiao, Liang Yan, Xin Dong Guo
https://www.sciencedirect.com/science/article/abs/pii/S0009308419301288
Regarding free genistein small delivery to the central nervous system, physico-chemical parameters of dimiristoylphosphatidylcholine liposome-loaded genistein were investigated, as well as its in vitro activity against the DPPH radical and glioma cells. Data obtained by UV–vis spectroscopy, Fourier Transform Infrared Spectroscopy, Nuclear Magnetic Resonance, Differential Scanning Calorimetry ...Author: Carla Roberta Lopes de Azambuja Borges, Nichole Osti Silva, Marisa Raquel Rodrigues, Marcelo Augusto...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359056/
The aim of this study was to design and characterize genistein-loaded chitosan nanoparticles for intranasal drug delivery, prepared by the ionic gelation technique by using sodium hexametaphosphate. Nanoparticles were characterized in vitro and their cytotoxicity was tested on PC12 cells.Author: Giovanna Rassu, Elena Piera Porcu, Silvia Fancello, Antonella Obinu, Nina Senes, Grazia Galleri, Ros...
https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/genistein
Various drug delivery systems including self-nano-emulsified system, super-magnetic system, and chitosan microspheres have been used to increase the dissolution and bioavailability of genistein. Genistein encapsulated in Fe 3 O 4 carboxymethylated chitosan nanoparticles had greater aqueous solubility than free genistein (Si et al., 2010).
https://biomaterialsres.biomedcentral.com/articles/10.1186/s40824-020-00187-2
Mar 20, 2020 · Fe 3 O 4-CMC-genistein drug delivery system could be considered as promising and futuristic carrier for natural compounds with anticancer effect such as genistein. Since very few drug carriers included both chitosan and magnetic nanoparticles have been reported, particularly on genistein, hence further study is necessity on other cancer cell ...
https://www.mdpi.com/1999-4923/11/1/8/htm
Genistein has been reported to have antioxidant and neuroprotective activity. Despite encouraging in vitro and in vivo results, several disadvantages such as poor water solubility, rapid metabolism, and low oral bioavailability limit the clinical application of genistein. The aim of this study was to design and characterize genistein-loaded chitosan nanoparticles for intranasal drug delivery ...Author: Giovanna Rassu, Elena Piera Porcu, Silvia Fancello, Antonella Obinu, Nina Senes, Grazia Galleri, Ros...
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