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https://www.sciencedirect.com/science/article/pii/S0169409X08000951
For example, these materials cannot serve as efficient agents for gene transfection or carriers for intracellular drug delivery because mammalian cells cannot efficiently engulf large particles via endocytosis. Also, mesoporous silica microspheres are within the size window of bacteria and could potentially trigger acute immune response in vivo.Author: Igor I. Slowing, Juan L. Vivero-Escoto, Chia-Wen Wu, Victor S.-Y. Lin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066571/
Dec 15, 2010 · These characteristics have led to applications in chemical and biochemical analytics, cosmetics, food technologies, and drug and gene delivery [7, 8]. There are numerous lipid formulations for each of these applications. However, this review will focus primarily on …Author: Daniel A. Balazs, Wt. Godbey
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171788/
Jul 03, 2018 · Nanocarriers have an important role in delivery of drug-gene combinations to cancer cells . Co-delivery vector based cationic polymer drug has many advantages, which include: 1- stimulate synergistic effect [ 63 ], 2- meliorate anti-tumor efficacy and systemic toxicity [ 64 ], 3- increase in cytotoxicity and drug absorption in tumor cells [ 65 ...Author: Abbas Zakeri, Mohammad Amin Jadidi Kouhbanani, Nasrin Beheshtkhoo, Vahid Beigi, Seyyed Mojtaba Mousa...
https://www.intechopen.com/books/application-of-nanotechnology-in-drug-delivery/electroporation-advantages-and-drawbacks-for-delivery-of-drug-gene-and-vaccine
Electroporation was introduced in the 1960s and comprises the application of controlled electric fields to facilitate cell permeabilization. The success of in vitro delivery by electroporation has led to the development of in vivo applications [Takei et al., 2008].The first in vitro and in vivo attempts to use electroporation in gene transfer were demonstrated in 1982 and 1991, respectively ...Author: Azam Bolhassani, Afshin Khavari, Zahra Orafa
https://pubs.acs.org/doi/abs/10.1021/acsnano.6b08393
The elevated Histidine content of S-19 appears critical to trigger endosomal escape by the proton sponge effect, thereby ensuring efficient gene transfection both in vitro and in vivo. Our study demonstrates that S-19 represents a promising functional protein nanocarrier that could be used for various drug and gene delivery applications.Author: Yuan Ping, Dawei Ding, Ricardo A. N. S. Ramos, Harini Mohanram, Kanagavel Deepankumar, Jianqing Gao,...
http://drugdelivery.chbe.gatech.edu/Papers/2001/Canatella%20Gene%20Therapy%202001.pdf
Electroporation gene and drug delivery PJ Canatella et al 1466 Gene Therapy Figure 2 Representative studies showing correlation predictions of electroporation-mediated gene transfection, viability and molecular uptake for the delivery of (a) luciferase gene to PC-12 cells;23 (b) CAT gene to U-937 cells;31 (c) human growth hormone gene to IMR-90 cells;17 (d) pNC9503 plasmidAuthor: PJ Canatella, Prausnitz
https://www.sciencedirect.com/science/article/pii/S0168365919306108
Transfection experiments with β-galactosidase on Chinese hamster ovarian cells showed that the gene complexed with a was the most effective of the delivery systems described herein. Further preliminary in vivo studies showed that a also facilitates the transportation of gene therapeutics into human embryonic kidney cells, as well as ...Author: Anna Kargaard, Anna Kargaard, Joost P.G. Sluijter, Bert Klumperman
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