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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191406/
Oct 13, 2014 · Tumor-targeted in vivo gene silencing via systemic delivery of cRGD-conjugated siRNA. ... Continuous systemic delivery of two different VEGFR2 cRGD-siRNAs resulted in down-regulation of corresponding mRNA (55 and 45%) and protein (65 and 45%) in tumors, as well as in overall reduction of tumor volume (90 and 70%). ... RNAi gene silencing ...Author: Xiaoxia Liu, Wei Wang, Dmitry Samarsky, Li Liu, Qian Xu, Wenqing Zhang, Guangzu Zhu, Ping Wu, Xialin...
https://www.ncbi.nlm.nih.gov/pubmed/26708003
Widespread Central Nervous System Gene Transfer and Silencing After Systemic Delivery of Novel AAV-AS Vector. ... Effective gene delivery to the central nervous system (CNS) is vital for development of novel gene therapies for neurological diseases. Adeno-associated virus (AAV) vectors have emerged as an effective platform for in vivo gene ...Author: Sourav R Choudhury, Anne F Harris, Damien J Cabral, Allison M Keeler, Ellen Sapp, Jennifer S Ferreir...
https://www.sciencedirect.com/science/article/pii/S0022283603001815
In mammalian cells, RNA duplexes of 21–23 nucleotides, known as small interfering RNAs (siRNAs) specifically inhibit gene expression in vitro.Here, we show that systemic delivery of siRNAs can inhibited exogenous and endogenous gene expression in adult mice.Author: Dag R. Sørensen, Marianne Leirdal, Mouldy Sioud
https://academic.oup.com/nar/article/42/18/11805/2435428
Sep 15, 2014 · Tumor-targeted in vivo gene silencing via systemic delivery of cRGD-conjugated siRNA Xiaoxia Liu. 1. Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China ... RNAi gene silencing technology, with siRNAs as its triggers, ...Author: Xiaoxia Liu, Wei Wang, Dmitry Samarsky, Li Liu, Qian Xu, Wenqing Zhang, Guangzu Zhu, Ping Wu, Xialin...
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)31709-9
Efficient Oncogene Silencing and Metastasis Inhibition via Systemic Delivery of siRNA. Previous Article The Host Response to Adenovirus, Helper-dependent Adenovirus, and Adeno-associated Virus in Mouse Liver. ... Both the in vitro and in vivo gene silencing results ...Author: Shyh Dar Li, Sumio Chono, Leaf Huang
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)32613-2
Gene Silencing via RNAi and siRNA Quantification in Tumor Tissue Using MEND, a Liposomal siRNA Delivery System. Yu Sakurai. Yu Sakurai. ... Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid. Gene Ther. 2007; 14: 68-77.Author: Yu Sakurai, Hiroto Hatakeyama, Yusuke Sato, Mamoru Hyodo, Hidetaka Akita, Hideyoshi Harashima
https://www.researchgate.net/publication/10841229_Gene_Silencing_by_Systemic_Delivery_of_Synthetic_siRNAs_in_Adult_Mice
Gene Silencing by Systemic Delivery of Synthetic siRNAs in Adult Mice Article in Journal of Molecular Biology 327(4):761-6 · May 2003 with 34 Reads How we measure 'reads'
https://www.nature.com/articles/s41417-019-0141-7
Nov 02, 2019 · Liposomes are one of the most widely investigated carriers for CRISPR/Cas9 delivery. The surface properties of liposomal carriers, including …Author: Shuai Zhen, Shuai Zhen, Xu Li, Xu Li
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