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https://www.sciencedirect.com/science/article/pii/S0378517301008614
Review Gene delivery with synthetic (non viral) carriers 1. Introduction. 2. Naked DNA. 3. Cationic lipids. 4. Polymers. 5. Polymeric vesicles. 6. Lipopolyplexes. 7. Preparation of non-viral gene delivery systems. 8. The therapeutic use of non-viral gene delivery systems. 9. Biological ...Author: Maureen D. Brown, Andreas G. Schätzlein, Ijeoma F. Uchegbu
https://www.researchgate.net/publication/11746751_Gene_delivery_with_synthetic_non_viral_carriers
Non-viral gene delivery involving the use of cationic polymer and cationic lipid based carriers still continues to enjoy a high profile due to the safety advantages offered by these systems when...
https://www.intechopen.com/books/recent-advances-in-novel-drug-carrier-systems/gene-delivery-systems-recent-progress-in-viral-and-non-viral-therapy
As seen in Figure 4, natural and synthetic polymers are used to prepare non-viral gene delivery systems. Compared to viral delivery systems, non-viral carriers are less toxic and immunogenic. Compared to viral delivery systems, non-viral carriers are less toxic and immunogenic.Author: Erdal Cevher, Ali Demir Sezer, Emre Şefik Çağlar
https://www.deepdyve.com/lp/elsevier/gene-delivery-with-synthetic-non-viral-carriers-1C2rhjn0o4
Oct 28, 2001 · Gene delivery with synthetic (non viral) carriers However, there are still problems associated with the use of these agents, notably their comparatively low efficiency and the inability to target gene expression to the area of pathology.
https://www.nature.com/articles/s41570-018-0039-1
Sep 21, 2018 · Abstract. The delivery of nucleic acids with transient activity for genetic engineering is a promising methodology with potential applications in the treatment of diseases ranging from cancer and infectious diseases to heritable disorders. Restoring the expression of a missing protein, correcting defective splicing of transcripts...Author: Irene Lostalé-Seijo, Javier Montenegro
https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
Gene delivery systems include viral vectors and non-viral vectors. Viral vectors are the most effective, but their application is limited by their immunogenicity, oncogenicity and the small size of the DNA they can transport. Non-viral vectors are safer, of …Author: Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís
https://www.sciencedirect.com/science/article/pii/S0168365907006220
Poly(l-lysine) (pLL) is one of the polymers that have been thoroughly investigated as a non-viral gene delivery vector . However, complexes of this polymer and DNA have relatively low transfection activity and a rather high toxicity, especially when high molecular weight pLL (Mw 25 kDa) is used.Author: Jordy Luten, Cornelus F. van Nostrum, Stefaan C. De Smedt, Wim E. Hennink
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · Although numerous viral and nonviral gene delivery systems have been developed in the last 3 decades, no delivery system has been designed that can be applied in gene therapy of all kinds of cell types in vitro and in vivo with no limitation and side effects.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347098/
Jan 01, 2015 · The optimal vector and delivery system depends on the target cells and its characteristics, duration of expression and the size of the genetic material to be incorporated in the vector [3,4].The present vectors used for gene therapy are broadly classified as Viral vectors, Non-viral vectors and engineered vectors. The non-viral vectors are Naked DNA, particle based and chemical …Author: Murali Ramamoorth, Aparna Narvekar
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