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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · In this helper-dependent vector system, one vector (the helper) contains all the viral genes required for replication but has a conditional gene defect in the packaging domain. The second vector contains only the ends of the viral genome, therapeutic gene sequences, and the normal packaging recognition signal,...
https://www.sciencedirect.com/science/article/pii/B9780123849649000050
The role of viral vectors in gene delivery is primary due to their function in the delivery of genetic material into host cells. However, the major problem in the use of viral vectors in gene therapy is immunogenic reaction risks and short-lived expression, which is of utmost importance to researchers.Author: Deepa H. Patel, Ambikanandan Misra
https://www.nature.com/articles/nrn1104
May 01, 2003 · The use of viral vectors to deliver genes to the nervous system shows great promise for both basic research and therapeutic applications. However, the brain presents a challenging target for gene delivery, because of its complex structure, compartmentalized functions and …Author: Beverly L. Davidson, Xandra O. Breakefield
https://seekingalpha.com/article/4305556-gene-therapy-series-2-delivery-systems-in-gene-therapy-including-viral-vectors
Nov 11, 2019 · Two of the most commonly used viruses as vectors in gene therapy include adeno-associated virus (AAV) and lentiviruses (LV). AAV-based transgene delivery is …
https://www.researchgate.net/publication/286315233_Gene_Delivery_Using_Viral_Vectors
The role of viral vectors in gene delivery is primary due to their function in the delivery of genetic material into host cells. However, the major problem in the use of viral vectors in gene therapy is immunogenic reaction risks and short-lived expression, which is of utmost importance to researchers.
https://www.ncbi.nlm.nih.gov/pubmed/9804053/
Although viral-mediated gene delivery has proved to be the most efficient means of gene transfer, nonviral means are also under development. Many of these nonviral systems incorporate portions of viral vectors to increase the efficiency of gene delivery or expression.Author: Paul D. Robbins, Steven C. Ghivizzani
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