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https://www.ncbi.nlm.nih.gov/pubmed/22523243
May 15, 2012 · Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber's hereditary optic neuropathy in a mouse model. Yu H(1), Koilkonda RD, Chou TH, Porciatti V, Ozdemir SS, Chiodo V, Boye SL, Boye SE, Hauswirth WW, Lewin AS, Guy J.Author: Hong Yu, Rajeshwari D. Koilkonda, Tsung Han Chou, Vittorio Porciatti, Sacide S. Ozdemir, Vince Chiod...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356643/
May 15, 2012 · MTS-Modified AAV for Import of DNA into Mitochondria. We asked whether the addition of an MTS to an AAV capsid protein could redirect import of AAV to mitochondria so as to deliver its DNA cargo, the ND4 subunit gene in this case, directly to the organelle. Mitochondrial ND4 can only be translated in the mitochondria and not on cytoplasmic ribosomes, because the TGA codon at amino …Author: Hong Yu, Rajeshwari D. Koilkonda, Tsung Han Chou, Vittorio Porciatti, Sacide S. Ozdemir, Vince Chiod...
http://www.pnas.org/content/109/20/E1238
May 15, 2012 · To introduce DNA into mitochondria efficiently, we fused adenoassociated virus capsid VP2 with a mitochondrial targeting sequence to carry the mitochondrial gene encoding the human NADH ubiquinone oxidoreductase subunit 4 ( ND4 ). Expression of WT ND4 in cells with the G11778A mutation in ND4 led to restoration of defective ATP synthesis.
https://www.pnas.org/content/109/20/E1238/1
May 15, 2012 · Fig. P1. Potential mechanisms of mitochondrial-targeting sequence (MTS)-targeted AAV entry into mitochondria, where the MTS AAV uncoats. The human ND4 subunit gene may combine by homologous recombination into the mouse mitochondrial genome, where it replaces the mouse ND4, or the heavy strand promoter-human ND4 may stay episomal and permit translation of the ND4 FLAG …Author: Hong Yu, Rajeshwari D. Koilkonda, Tsung Han Chou, Vittorio Porciatti, Sacide S. Ozdemir, Vince Chiod...
https://pubs.acs.org/doi/10.1021/jacs.0c00188
Mitochondria play a key role in oncogenesis and constitute one of the most important targets for cancer treatments. Although the most effective way to deliver drugs to mitochondria is by covalently linking them to a lipophilic cation, the in vivo delivery of free drugs still constitutes a critical bottleneck. Herein, we report the design of a mitochondria-targeted metal–organic framework ...Author: Salame Haddad, Isabel Abanades Lazaro, Marcus Fantham, Ajay Mishra, Joaquin Silvestre-Albero, Johann...
https://www.researchgate.net/publication/224811735_Gene_delivery_to_mitochondria_by_targeting_modified_adenoassociated_virus_suppresses_Leber's_hereditary_optic_neuropathy_in_a_mouse_model
Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber's hereditary optic neuropathy in a mouse model. ... hanced their delivery to mitochondria (29, 37), but ...
https://www.academia.edu/13245033/Gene_delivery_to_mitochondria_by_targeting_modified_adenoassociated_virus_suppresses_Lebers_hereditary_optic_neuropathy_in_a_mouse_model
Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber's hereditary optic neuropathy in a mouse model
https://miami.pure.elsevier.com/en/publications/gene-delivery-to-mitochondria-by-targeting-modified-adenoassociat
To introduce DNA into mitochondria efficiently, we fused adenoassociated virus capsid VP2 with a mitochondrial targeting sequence to carry the mitochondrial gene encoding the human NADH ubiquinone oxidoreductase subunit 4 (ND4). Expression of WT ND4 in cells with the G11778A mutation in ND4 led to restoration of defective ATP synthesis.Author: Hong Yu, Rajeshwari D. Koilkonda, Tsung Han Chou, Vittorio Porciatti, Sacide S. Ozdemir, Vince Chiod...
https://europepmc.org/articles/PMC3356643
Apr 20, 2012 · Mutant NADH dehydrogenase subunit 4 gene delivery to mitochondria by targeting sequence-modified adeno-associated virus induces visual loss and optic atrophy in mice. Yu H, Ozdemir SS, Koilkonda RD, Chou TH, Porciatti V, Chiodo V, Boye SL, Hauswirth WW, Lewin AS, Guy JAuthor: Hong Yu, Rajeshwari D. Koilkonda, Tsung Han Chou, Vittorio Porciatti, Sacide S. Ozdemir, Vince Chiod...
https://www.sciencedirect.com/science/article/pii/B9780128177761000055
The vesicle formation of dequalinium chloride (DQA) was discovered by Prof. Volkmar Weissig in 1998, and was the first mitochondria-targeted nano carrier , .DQAsomes were reported for mitochondrial targeting vectors to be used as gene-delivery systems , .Dequalinium (1,1′-decamethylene bis-4-aminoquinaldinium chloride; DQA) is a cationic bola amphiphilic compound composed of two …Author: Saravana Babu Chidambaram, Bipul Ray, Abid Bhat, Arehally Marappa Mahalakshmi, Tuladhar Sunanda, Pad...
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