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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865214/
Introduction. O ne prerequisite for effective cardiac gene therapy is the need for a reliable, safe, and clinically relevant delivery system to the human myocardium. Although a great number of methods have been identified, each has significant limitations. The theoretically ideal method of cardiac gene delivery would be to use a vector that could be administered intravenously, with globally ...Author: Michael G. Katz, JaBaris D. Swain, Jennifer D. White, David Low, Hansell Stedman, Charles R. Bridges
https://www.ncbi.nlm.nih.gov/pubmed/19947886
Review of available techniques suggests that an optimal method for vector-mediated gene delivery to the large animal myocardium would ideally employ retrograde and/or anterograde transcoronary gene delivery,extended vector residence time in the coronary circulation, an increased myocardial transcapillary gradient using physical methods ...Author: Michael G. Katz, JaBaris D. Swain, Jennifer D. White, David Low, Hansell Stedman, Charles R. Bridges
https://academic.oup.com/cardiovascres/article/73/3/453/367211
Feb 01, 2007 · This review article will give an overview of different vector and delivery systems that have been tested in the heart, and will discuss chances, limitations and new developments in cardiac gene therapy. 2. Delivery barriers of cardiac gene transferAuthor: Oliver J. Müller, Hugo A. Katus, Raffi Bekeredjian
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.311587
Myocardial gene therapy has been tested in patients with heart failure using adeno-associated vectors with no safety concerns but lacking clinical improvements. Cardiac gene therapy is adapting to the new developments in vectors, delivery systems, targets, and clinical end points and is …Author: Kiyotake Ishikawa, Thomas Weber, Roger J. Hajjar
http://www.nature.com/articles/gt201211
Mar 15, 2012 · Recently there have been advances in direct and transvascular gene delivery methods with the use of new technologies. ... Fish K, Hajjar RJ . Gene delivery methods in cardiac gene therapy. J …Author: M G Katz, M G Katz, A S Fargnoli, A S Fargnoli, L A Pritchette, C R Bridges, C R Bridges
https://www.ahajournals.org/doi/full/10.1161/circresaha.111.252981
Other Delivery Methods. Most cardiac gene transfer studies focus on the left ventricle. ... Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): a phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum …Author: Lisa Tilemann, Kiyotake Ishikawa, Thomas Weber, Roger J. Hajjar
https://link.springer.com/book/10.1007/978-1-4939-6588-5
This detailed book provides methodological information on cardiac gene delivery, from classic to state-of-the-art technologies and techniques. Efficient, cardiac-specific, and safe vectors, as well as refined vector delivery methods, are key for successful cardiac gene transfer and eventually for …
https://www.liebertpub.com/doi/10.1089/hum.2009.164
Mar 15, 2010 · Vector-mediated cardiac gene therapy holds tremendous promise as a translatable platform technology for treating many cardiovascular diseases. The ideal technique is one that is efficient and practical, allowing for global cardiac gene expression, while …Author: Michael G. Katz, JaBaris D. Swain, Jennifer D. White, David Low, Hansell Stedman, Charles R. Bridges
https://www.onlinelibrary.wiley.com/doi/abs/10.1002/jgm.1609
The Journal of Gene Medicine. Volume 13, Issue 10. Review Article. Free Access. Gene delivery methods in cardiac gene therapy. Kiyotake Ishikawa. Cardiovascular Research Center, Mount Sinai School of Medicine, New York, NY, USA ...Author: Kiyotake Ishikawa, Lisa Tilemann, Kenneth Fish, Roger J. Hajjar
https://www.sciencedirect.com/science/article/pii/S0378517313010351
Gene therapy is a promising new technique for treating many serious incurable diseases, such as cancer and genetic disorders. The main problem limiting the application of this strategy in vivo is the difficulty of transporting large, fragile and negatively charged molecules like DNA into the nucleus of the cell without degradation. The key to success of gene therapy is to create safe and ...Author: D. Ibraheem, A. Elaissari, H. Fessi
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