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https://www.ncbi.nlm.nih.gov/pubmed/21046520
Gene Based Vaccines: Optimising Development and Delivery - A marcus evans Conference. Garren H(1). Author information: (1)Bayhill Therapeutics Inc, 1804 Embarcadero Road, Suite 201, Palo Alto, CA 94303, USA. [email protected]: Garren H
https://en.wikipedia.org/wiki/DNA_vaccination
DNA vaccination is a technique for protecting against disease by injection with genetically engineered plasmid containing the DNA sequence encoding the antigen(s) against which an immune response is sought so cells directly produce an antibody, producing a protective immunological response. DNA vaccines have potential advantages over conventional vaccines, including the ability to induce a ...
https://www.researchgate.net/publication/12386650_Gene-Based_Vaccines
Gene-based vaccines thus could be considered a sub- ... There is agreement that for the time being animals will still be needed for the development of vaccines in order to gain best knowledge on ...
https://www.researchgate.net/publication/12256898_Delivery_Systems_for_Gene-based_Vaccines
Delivery Systems for Gene-based Vaccines. ... Promising approaches based on the delivery of genes, either as plasmid DNA or by viral vectors, have been extensively evaluated pre-clinically and in ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1949980/
Delivery systems for gene-based vaccines. T. W. Dubensky, Jr, M. A. Liu, and J. B. Ulmer ... This manuscript reviews recent developments for gene-based vaccines, specifically, new approaches for formulating and delivering plasmid DNA and alphaviral replicon vectors, all of which have resulted in increased potency of gene-based vaccines. ...Author: Thomas W. Dubensky, Margaret A. Liu, Jeffrey B. Ulmer
https://www.sciencedirect.com/science/article/pii/S1471491406000657
Gene-based vaccines: recent technical and clinical advances. ... This highlights an inherent complication related to mixing immune potentiators with DNA vaccines, and formulation development might be required to ensure that the adjuvant and expressed antigen are temporally and spatially aligned. ... Interest in gene-based vaccines for HIV ...Author: Jeffrey B. Ulmer, Britta Wahren, Margaret A. Liu
https://www.sciencedirect.com/science/article/pii/S0939641117313346
Despite DNA vaccines demonstrating good safety and tolerability, the induction of meaningful immune responses through simple injection has proven difficult to achieve in human trials, because of the extra- and intracellular biological barriers to gene delivery , .Author: Grace Cole, Ahlam A. Ali, Cian M. McCrudden, John W. McBride, Joanne McCaffrey, Tracey Robson, Vicky...
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