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https://www.sciencedirect.com/science/article/pii/B9780128136638000130
Gemini surfactants, N,N-bis(dimethylalkyl)-α,ω-alkanediammonium halide derivatives, are attracting increasing interest in the fields of drug and gene delivery.This arises from the flexibility in chemical modification of these compounds that can modulate their physicochemical properties.Author: Amal Makhlouf, Istvan Hajdu, Ildiko Badea
https://www.sciencedirect.com/science/article/pii/S1010603017309632
Gemini surfactant (GS) has been proved to be a powerful system for nonviral gene delivery. Herein, a family of tetraphenylethylene (TPE)-based GS possessing different lengths of hydrophobic tails and different linkages between the TPE and [12]aneN 3 moieties (1a, 2a, 1b and 2b) were synthesized for facilitating DNA condensation, promoting gene transfection and tracing cellular fate of GS/DNA ...Author: Ke-Xin Zhang, Ai-Xiang Ding, Zheng-Li Tan, You-Di Shi, Zhong-Lin Lu, Lan He
https://pubs.acs.org/doi/10.1021/mp5005349
Gene delivery targeting mitochondria has the potential to transform the therapeutic landscape of mitochondrial genetic diseases. Taking advantage of the nonuniversal genetic code used by mitochondria, a plasmid DNA construct able to be specifically expressed in these organelles was designed by including a codon, which codes for an amino acid only if read by the mitochondrial …Author: Ana M. Cardoso, Catarina M. Morais, A. Rita Cruz, Ana L. Cardoso, Sandra G. Silva, M. Luísa do Vale,...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122513/
High gene delivery efficiency of alkylated low-molecular-weight polyethylenimine through gemini surfactant-like effect. ... highly stable micelle-like particles and that they triggered the coil–globule transition of DNA similarly to cationic surfactant and possessed high gene delivery efficacy in vitro and in vivo. Materials and methods.Author: Shan Liu, Wei Huang, Ming-Ji Jin, Qi-Ming Wang, Gan-Lin Zhang, Xiao-Min Wang, Shuai Shao, Zhong-Gao ...
https://pubs.acs.org/doi/abs/10.1021/mp5005349
Gene delivery targeting mitochondria has the potential to transform the therapeutic landscape of mitochondrial genetic diseases. Taking advantage of the nonuniversal genetic code used by mitochondria, a plasmid DNA construct able to be specifically expressed in these organelles was designed by including a codon, which codes for an amino acid only if read by the mitochondrial …Author: Ana M. Cardoso, Catarina M. Morais, A. Rita Cruz, Ana L. Cardoso, Sandra G. Silva, M. Luísa do Vale,...
https://link.springer.com/protocol/10.1007%2F978-1-4939-9516-5_14
May 31, 2019 · Abstract. Diquaternary ammonium-based gemini surfactants have been investigated widely as nonviral gene delivery systems. These unique cationic lipids have versatility in their chemical structure, show relatively low toxicity, are able to compact genetic material (pDNA, RNA) into nano-sized lipoplexes, and can be easily produced.Author: Mays Al-Dulaymi, Waleed Mohammed-Saeid, Waleed Mohammed-Saeid, Anas El-Aneed, Ildiko Badea
https://www.researchgate.net/publication/23796667_Gemini_Surfactant_Based_Carriers_in_Gene_and_Drug_Delivery
Gemini surfactants are promising molecules utilized as non-viral gene delivery vectors. However, little is known about their cellular uptake and distribution after they release their therapeutic ...
https://www.ncbi.nlm.nih.gov/pubmed/25513958
In this work, novel serine-derived gemini surfactants, differing in alkyl chain lengths and in the linker group bridging the spacer to the headgroups (amine, amide and ester), were evaluated for their ability to mediate gene delivery either per se or in combination with helper lipids.Author: Ana M. Cardoso, Catarina M. Morais, A. Rita Cruz, Sandra G. Silva, M. Luísa do Vale, Eduardo F. Marq...
https://www.researchgate.net/publication/269730300_New_Serine-derived_Gemini_surfactants_as_gene_delivery_systems
Gemini surfactants have been extensively used for in vitro gene delivery. Amino acid-derived gemini surfactants combine the special aggregation properties characteristic of the gemini surfactants ...
http://www.eurekaselect.com/68271/article
Abstract: Lipid-based drug carriers, such as liposomes or drug/lipid complexes, have been extensively investigated in a large number of therapeutic protocols such as gene therapy, drug delivery, drug targeting and antibacterial treatments, in preclinical and clinical trials.
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