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https://www.sciencedirect.com/science/article/pii/S0014305718325059
In drug delivery, medicines are entrapped within gelatin matrix from which they are released in erosion- and/or diffusion-controlled manners. However, due to the low stability and mechanical strength of gelatin, the pharmacological shortcomings of conventional gelatin drug delivery systems result in nonspecific distribution, undesirable side effects and toxicity of drugs.Author: Alaitz Etxabide, Alaitz Etxabide, Jingjunjiao Long, Pedro Guerrero, Koro de la Caba, Ali Seyfoddin
https://www.ncbi.nlm.nih.gov/pubmed/22356721
Scaffold matrices can be used to achieve drug delivery with high loading and efficiency to specific sites. Biomaterials used for fabrication of scaffold may be natural polymers such as alginate, proteins, collagens, gelatin, fibrins, and albumin, or synthetic polymers such as polyvinyl alcohol and polyglycolide.Author: Tarun Garg, Onkar Singh, Saahil Arora, R. S. R. Murthy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622783/
Therefore, nanofiber scaffolds can be a suitable platform for oral mucosal drug delivery. Nonetheless, utility of nanofiber scaffolds for oral candidiasis treatment has yet to be fully explored. In this work, we fabricated gelatin nanofiber scaffolds via electrospinning and explore them for local delivery of therapeutics for candidiasis.Author: Donald C. Aduba, Jeremy A. Hammer, Quan Yuan, W. Andrew Yeudall, Gary L. Bowlin, Hu Yang
https://www.mdpi.com/1996-1944/13/7/1763/htm
Gelatin has been shown to form 3D ordered macroporous structures for applications in oral drug delivery and regenerative tissue engineering [44,45,46,47,48]. The characteristic triple-stranded helix structure of collagen is partially retained in gelatin.
http://www.ijpsnonline.com/Issues/113.pdf
Vikas V. Gaikwad et al. : Scaffolds for Drug Delivery in Tissue Engineering 117 Collagen and gelatin Collagen is a major structural component of connective tissues and organs. Surface immobilization of collagen is one of the most established methods for modulating the adhesive properties to the scaffolds.
https://onlinelibrary.wiley.com/doi/10.1002/app.47590
In this work, chitosan–gelatin/zinc oxide nanocomposite hydrogel scaffolds (CS–GEL/nZnO) were prepared via in situ synthesis of ZnO nanoparticles (nZnO) to reach a scaffold with both inherent antibacterial and drug delivery properties. The prepared nanocomposite hydrogel scaffolds were characterized using scanning electron microscopy, transmission electron microscopy, atomic …Author: Rasul Rakhshaei, Hassan Namazi, Hamed Hamishehkar, Hossein Samadi Kafil, Roya Salehi
https://www.nature.com/articles/s41598-018-20006-y
Jan 25, 2018 · Gelatin is a partial hydrolysis product of native collagen and characterized by non-toxicity, non-carcinogenicity, biocompatibility, and biodegradability; gelatin is widely used in the pharmaceutical and medical fields, such as in wound dressing materials, tissue engineering scaffolds, and drug delivery …Author: Yang G, Xiao Z, Long H, Ma K, Zhang J, Ren X
https://www.researchgate.net/publication/221853404_Scaffold_A_Novel_Carrier_for_Cell_and_Drug_Delivery
Scaffold matrices can be used to achieve drug delivery with high loading and efficiency to specific sites. Biomaterials used for fabrication of scaffold may be natural polymers such as alginate, proteins, collagens, gelatin, fibrins, and albumin, or synthetic polymers such as polyvinyl alcohol and polyglycolide.
https://www.sciencedirect.com/science/article/pii/S0927776510007071
May 01, 2011 · It was almost 100% for the composite scaffold after 1500 min. A burst release was observed from the release profile of FBF-loaded PLGA/gelatin (9/1) nanofibrous scaffold. Due to the diffusion-controlled release of the drug and the higher water adsorption of the scaffold, therefore the drug molecule had a more rapid diffusion from the matrix into the aqueous medium .Author: Z.X. Meng, X.X. Xu, W. Zheng, H.M. Zhou, L. Li, Y.F. Zheng, Y.F. Zheng, X. Lou, X. Lou
https://www.researchgate.net/publication/272748016_Gelatin_Based_Scaffolds_For_Tissue_Engineering_-_A_review
Gelatin Based Scaffolds For Tissue Engineering – A review. Current strategies of regenerative medicine are focused on the restoration of pathologically altered tissue architecture by transplantation of cells in combination with supportive scaffolds and biomolecules.
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