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https://www.sciencedirect.com/science/article/pii/B978012391858100006X
Anti-inflammatory peptides such as the somatostatin analogs octreotide, lanreotide, and vapreotide are now clinically available to treat GI tumors (Froidevaux and Eberle, 2002). Once coupled to drug delivery nanocarriers (NPs, liposomes, etc.), anti-inflammatory peptides have tremendous results as the peptide has a high activity and specificity.Author: Hamed Laroui, Shanthi V. Sitaraman, Didier Merlin
https://www.researchgate.net/publication/224924886_Gastrointestinal_Delivery_of_Anti-inflammatory_Nanoparticles
Local delivery of anti-inflammatory drugs loaded in nanoparticles to the inflamed colonic site is of great interest for inflammatory bowel disease (IBD) treatment.
https://www.sciencedirect.com/science/article/pii/S0378517314004992
pH-sensitive nanoparticles for colonic delivery of curcumin in inflammatory bowel disease. ... Local delivery of anti-inflammatory drugs loaded in nanoparticles to the inflamed colonic site is of great interest for inflammatory bowel disease (IBD) treatment. Curcumin (CC) is an anti-inflammatory local agent, which presents poor ADME properties.Author: Ana Beloqui, Régis Coco, Patrick B. Memvanga, Patrick B. Memvanga, Bernard Ucakar, Anne des Rieux, V...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822607/
The gastrointestinal tract is a site of complex, symbiotic interactions between host cells and the resident microbiome. Accordingly, evaluation of nanoparticles must take into consideration not only absorption and extraintestinal organ accumulation but also the potential for altered gut microbes and the effects of this perturbation on the host.Author: Ingrid L. Bergin, Frank A. Witzmann
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826879/
Inflammatory bowel disease (IBD) causes inflammation to the gastrointestinal tract. Local administration of Anti-inflammatory drugs such as 5-aminosalysilic acid (5-ASA) can alleviate the symptoms of IBD. The application of nanoparticles for IBD treatment in direct rectal administration showed high drug availability and treatment efficacy.Author: Zahra Davoudi, Nathan Peroutka-Bigus, Bryan Bellaire, Michael Wannemuehler, Terrence Barrett, Balaji...
https://www.researchgate.net/publication/263734453_PH-sensitive_nanoparticles_for_colonic_delivery_of_curcumin_in_inflammatory_bowel_disease
Recently, a similar drug delivery system, polymeric nanoparticles of PLGA and Eudragite® S100 loaded with curcumin, an anti-inflammatory agent, was presented for inflammatory bowel disease [269 ...
http://jpet.aspetjournals.org/content/299/2/775
Nov 01, 2001 · The use of nanoparticles for targeted oral drug delivery to the inflamed gut tissue in inflammatory bowel disease was examined. Such a strategy of local drug delivery would be a distinct improvement compared with existing colon delivery devices for this disease. An experimental colitis was induced by trinitrobenzenesulfonic acid to male Wistar rats. Rolipram, an anti-inflammatory model drug ...
https://iopscience.iop.org/article/10.1088/2043-6254/aad5d5/pdf
of mesoporous silica nanoparticles (MSN) to enhance curcumin bioavailability significantly. In the present work, we investigated anti-inflammatory effects of the curcumin-MSN and related side effects caused to the gastrointestinal tract and kidney, compared with curcumin and diclofenac sodium.Author: Lannie Hadisoewignyo, Sandy Budi Hartono, Angelica Kresnamurti, Ivonne Soeliono, Yolenta Nataline, G...
https://sciencebeta.com/chitosan-nanoparticles/
Apr 08, 2016 · Nanoparticles designed to block a cell-surface molecule playing a key role in inflammation could be a safe treatment for inflammatory bowel disease (IBD), according to researchers in the Institute for Biomedical Sciences at Georgia State University and Southwest University in China. The scientists developed chitosan nanoparticles, or microscopic particles, to reduce the expression of CD98, […]
https://www.cambridge.org/core/journals/mrs-bulletin/news/ginger-derived-nanoparticles-prevent-and-treat-inflammatory-bowel-disease-in-mice
The ginger-derived nanoparticles (220–290 nm in diameter) represent a novel, natural, nontoxic delivery system, which targets the inflamed intestinal mucosa, blocks damaging factors while promoting pro-healing factors, and could easily be developed for large-scale production aimed at the treatment of IBD, researchers say.
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