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https://www.sciencedirect.com/science/article/pii/S2162253118301306
Gemcitabine-Incorporated G-Quadruplex Aptamer for Targeted Drug Delivery into Pancreas Cancer. ... It is known that G-quadruplex-forming oligonucleotides are relatively stable against nuclease degradation.27, 28 The high serum stability of guanine-rich APTA-12 can be explained by its stable G-quadruplex structure.Author: Jun Young Park, Ye Lim Cho, Ju Ri Chae, Sung Hwan Moon, Won Gil Cho, Yun Jung Choi, Soo Jin Lee, Won...
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(18)30130-6
Sep 07, 2018 · Gemcitabine-Incorporated G-Quadruplex Aptamer for Targeted Drug Delivery into Pancreas Cancer. Jun Young Park. Jun Young Park. Affiliations. Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.Author: Jun Young Park, Ye Lim Cho, Ju Ri Chae, Sung Hwan Moon, Won Gil Cho, Yun Jung Choi, Soo Jin Lee, Won...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077122/
Sep 07, 2018 · Gemcitabine-Incorporated G-Quadruplex Aptamer for Targeted Drug Delivery into Pancreas Cancer. Jun Young Park, 1, 3 Ye Lim Cho, 1 Ju Ri Chae, 1 Sung Hwan Moon, 2 Won Gil Cho, 3 Yun Jung Choi, 4 Soo Jin Lee, 2, ... and gemcitabine-containing oligonucleotides were annealed to the aptamer for targeted drug delivery.Author: Jun Young Park, Ye Lim Cho, Ju Ri Chae, Sung Hwan Moon, Won Gil Cho, Yun Jung Choi, Soo Jin Lee, Won...
https://www.nature.com/articles/s41598-019-44388-9
May 28, 2019 · Aptamer-based Targeted Delivery of a G-quadruplex Ligand in Cervical Cancer Cells ... we have evaluated AS1411 and its modified derivatives designated by LNA-AS1411 and U-AS1411 as drug delivery ...Author: Josué Carvalho, Artur Paiva, Artur Paiva, Maria Paula Cabral Campello, António Paulo, Jean-Louis Mer...
http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1568-0266&volume=15&issue=19&spage=1988
We would summarize some typical systems, utilizing G-quadruplex as signal readout unit, for various target detection, such as SNP, miRNAs, ions, transcription factors and so on. On the other hand, its use in drug delivery always relies on probes’ structural change, as the switch of drug release.Author: Tian Tian, Heng Xiao, Xiang Zhou
https://www.cell.com/molecular-therapy-family/nucleic-acids/pdfExtended/S2162-2531(18)30130-6
Gemcitabine-Incorporated G-Quadruplex Aptamer for Targeted Drug Delivery into Pancreas Cancer Jun Young Park, 1, 3Ye Lim Cho, Ju Ri Chae,1 Sung Hwan Moon, 2Won Gil Cho, Yun Jung Choi,4 Soo Jin Lee, and Won Jun Kang1
https://pubs.acs.org/doi/10.1021/acsabm.9b00334
The ultimate aim in developing controlled drug delivery systems is to derive formulations to achieve drug release at a constant rate over a long duration. The drug release profile that follows zero-order kinetics is crucial for reduction in the drug administration frequency, reduced cytotoxicity, and improved convenience and compliance of patients.Author: Neha Thakur, Bhagwati Sharma, Suman Bishnoi, Siddarth Jain, Debasis Nayak, Tridib K. Sarma
https://pubs.acs.org/doi/10.1021/acs.nanolett.8b02732
G-Quadruplex-Based Nanoscale Coordination Polymers to Modulate Tumor Hypoxia and Achieve Nuclear-Targeted Drug Delivery for Enhanced Photodynamic Therapy Yu Yang State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, ChinaAuthor: Yu Yang, Wenjun Zhu, Liangzhu Feng, Yu Chao, Xuan Yi, Ziliang Dong, Kai Yang, Weihong Tan, Zhuang Li...
https://www.ncbi.nlm.nih.gov/pubmed/30195790
Sep 07, 2018 · Gemcitabine-Incorporated G-Quadruplex Aptamer for Targeted Drug Delivery into Pancreas Cancer. ... In the current study, we constructed an aptamer-based gemcitabine delivery system, APTA-12, and assessed its therapeutic effects on pancreatic cancer cells in vitro and in vivo. APTA-12 was effective in vitro and in vivo in pancreatic cancer cells ...Author: Jun Young Park, Ye Lim Cho, Ju Ri Chae, Sung Hwan Moon, Won Gil Cho, Yun Jung Choi, Soo Jin Lee, Won...
https://www.researchgate.net/publication/325784565_Gemcitabine-Incorporated_G-Quadruplex_Aptamer_for_Targeted_Drug_Delivery_into_Pancreas_Cancer
Gemcitabine-Incorporated G-Quadruplex Aptamer for Targeted Drug Delivery into Pancreas Cancer Article (PDF Available) in Molecular Therapy - Nucleic Acids 12 · June 2018 with 206 Reads
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