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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890573/
FLNa WT cells exhibited larger adhesions (~30%, P < 0.01) than FLNa KD cells at ~ 6 hours after initial cell attachment (Figure 6f). We estimated the strength of adhesions by applying shear forces at 0, 2, or 6 hours after initial cell attachment to collagen.
https://cie.gov.ar/web/images/01LNAPL-Behaviour_Basic_Sep_2018_final_Spanish_MLS_Rosario.pdf
FLNA Y FLNA LIBRE (FASE LIBRE) Si de identifica afectación en agua subterránea, vapores o suelo, es muy probable que exista FLNA en el subsuelo. La misma podrá, o no, moverse hasta un pozo de monitoreo. Metodologías tradicionales de destino y transporte comúnmente son aceptables cuando FLNA no se encuentra en el pozo de monitoreo.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123018
We found that the presence of FLNA is associated with higher total and plasma membrane PC2 protein expression. Western blotting analysis in combination with FLNA KD showed that FLNA in A7 cells represses PC2 degradation, prolonging the half-life from 2.3 to …
https://medlineplus.gov/genetics/gene/flna/
Frontometaphyseal dysplasia. More than 15 mutations in regions of the FLNA gene called exons 4, 22, 29, 33, and 44 through 46 have been identified in people with frontometaphyseal dysplasia. This condition is a member of a group of related conditions called otopalatodigital spectrum disorders, which also includes otopalatodigital syndrome type 1, otopalatodigital syndrome …
https://www.omim.org/entry/300017
Crystal Structure. Clark et al. (2009) determined the crystal structures of wildtype and E254K (300017.0010)-mutant FLNA actin-binding domains (ABDs) at 2.3-angstrom resolution, revealing that they adopt similar closed conformations.The E254K mutation removes a conserved salt bridge but does not disrupt the ABD structure. The solution structures are also equivalent as …
https://www.pnas.org/content/100/8/4562
Construction of Plasmids. The AR hinge deletion mutant AR(Δ628–646) was constructed as described ().The primer extension method of Higuchi et al. was used to create AR hinge mutants AR(Δ622–670) and AR(Δ647–670). pCMV-FLNa was created by first transferring a fragment containing amino acid residues 21–2647 from the full-length FLNa plasmid, kindly …
https://www.nature.com/articles/s41598-021-94330-1
The expression of FLNA, CLU, CAP1 was increase in the HCC group when compare with the healthy group (p-value < 0.0001 in FLNA and CLU and p-value = 0.4663). Full size image
https://en.wikipedia.org/wiki/FLNA
FLNA editing site is 2 nucleotides from a splice site like the R/G site of GluR-2. Both transcripts have 7/8 identical nucleotides around their editing sites. Since it is widely thought that editing at the GLUR-2 Q/R site influences splicing, the sequence and editing site similarity could mean that editing at the FLNA site could also regulate ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2198874/
Increased actin content in lamellar regions of cells lacking FLNa. Serum-starved M2 cells treated with serum for 10 min show F-actin staining in the entire flat, lamellar region that surrounds the cell periphery, and the staining reveals fine projections (Fig. 1 A).Identically treated A5 and A7 cells show linear strands of F-actin staining throughout the cell and around the …
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