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https://www.researchgate.net/publication/38033709_Novel_pMDI_formulations_for_pulmonary_delivery_of_proteins
Thus, formulation of pMDI suspensions using NaCMC-based spray-dried powders is a promising approach for the pulmonary delivery of proteins and peptides. Discover the world's research 15+ million ...
https://link.springer.com/article/10.1007/s11095-018-2452-z
Aug 23, 2018 · Pulmonary delivery of biologics is of great interest, as it can be used for the local treatment of respiratory diseases or as a route to systemic drug delivery. To reach the full potential of inhaled biologics, a formulation platform capable of producing high performance aerosols without altering protein native structure is required.Author: Erin M. Wilson, J. Christopher Luft, Joseph M. DeSimone, Joseph M. DeSimone
https://www.sciencedirect.com/science/article/pii/S0169409X14002117
Protein inhalation is a delivery route which offers high potential for direct local lung application of proteins. Liquid formulations are usually available in early stages of biopharmaceutical development and nebulizers are the device of choice for atomization avoiding additional process steps like drying and enabling fast progression to clinical trials.Author: Sebastian P. Hertel, Gerhard Winter, Wolfgang Friess
https://www.sciencedirect.com/science/article/pii/S0378517306001360
6. Problems facing pulmonary delivery of proteins/peptides and possible solutions. The delivery of proteins/peptides for systemic activity via the pulmonary route looks quite promising but there are some limitations facing this route and various studies have been performed with a view to finding lasting solutions to these limitations.Author: Sunday A. Shoyele, Alex Slowey
https://link.springer.com/chapter/10.1007%2F978-3-642-59990-3_3
The use of proteins as drugs is by no means new. Insulin, gamma-globulin and protein-containing vaccines have been routinely employed for decades. However, the advent of …Author: C. R. Middaugh, R. Pearlman
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374550/
Pulmonary route of delivery: Pulmonary administration is an attractive route of proteins and peptides than other alternative routes of administration. The lungs offer a large surface area for drug absorption, of approximately 80-140 m 2. The alveolar epithelium is very thin (approximately 0.1–0.5 mm thick), thereby permitting rapid drug ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948054/
With proven efficacy in delivery to a variety of cultured, primary cells and tumour cells together with the first example of in vivo tolerance and efficacy, we were interested to develop a pH responsive peptide-based formulation that is suitable for effective nucleic acid delivery by pulmonary administration.Author: Wanling Liang, Philip C.L. Kwok, Philip C.L. Kwok, Michael Y.T. Chow, Patricia Tang, A. James Mason,...
https://www.pharmatutor.org/articles/pulmonary-drug-delivery-a-review
Home » PULMONARY DRUG DELIVERY: A REVIEW. PULMONARY DRUG DELIVERY: A REVIEW . ... recent advances show great promise, but pulmonary delivery of peptides and proteins is complicated by the complexity of the anatomic structure of the human respiratory system and the effect of disposition exerted by the respiration process. ... Poor formulation ...
https://www.ondrugdelivery.com/pulmonary-delivery-antimicrobial-peptides/
nanocarriers for pulmonary delivery of peptides Figure 2: Schematic illustration of the possible action mechanisms of antimicrobial peptides interacting with cell membranes. 13 As soon as they enter the body, AMPs, as well as other peptides and proteins, are attacked by proteases, which break them down into amino acids and shorter fragments.
https://www.liebertpub.com/doi/abs/10.1089/jamp.2010.0838
Dec 06, 2010 · Formulation technologies to overcome unfavorable properties of peptides and proteins for pulmonary delivery Drug Discovery Today: Technologies, Vol. 9, No. 2 Constant size, variable density aerosol particles by ultrasonic spray freeze dryingAuthor: Jeffry G. Weers, John Bell, Hak-Kim Chan, David Cipolla, Craig Dunbar, Anthony J. Hickey, Ian J. Smi...
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