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https://medicalxpress.com/news/2020-04-fatty-acid-triglycerides-effective-platform.html
10 days ago · Houston Methodist nanomedicine researchers are studying this new drug delivery system for a diabetes drug that resulted in approximately ... Fatty acid in triglycerides proves an effective ...
https://www.eurekalert.org/pub_releases/2020-04/hm-fai033020.php
11 days ago · Fatty acid in triglycerides proves an effective platform for biological drug delivery Houston Methodist
https://www.sciencedirect.com/science/article/pii/S2211383513000919
Oral lipid-based drug delivery systems – an overview ... fatty acid composition, HLB value, ... A. Dahan, A. HoffmanRationalizing the selection of oral lipid based drug delivery systems by an in vitro dynamic lipolysis model for improved oral bioavailability of poorly water soluble drugs.Author: Sandeep Kalepu, Mohanvarma Manthina, Veerabhadhraswamy Padavala
https://www.sciencedirect.com/science/article/pii/S0899900718304180
OA is a monounsaturated fatty acid (MUFA), whereas LA is a PUFA, and in fat-deficient microsomes it is hypothesized that LA is substituted with OA. ... Ocular drug delivery to the posterior region of the eye has been a task for all scientists working in this domain and a considerable amount of progress has been made in this area.Author: Aakash Katdare, Shreya Thakkar, Shivshankar Dhepale, Dignesh Khunt, Manju Misra
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537895/
Oct 15, 2013 · 2.2. Triglyceride formulations. Alternatively fatty acids can be used to elude first-pass metabolism by disguising a drug as a triglyceride. Valproic acid was esterified at the sn-2 position on the glycerol backbone of lysophosphatidylcholine [].This molecule showed an ability to absorb across the gut lumen of rats and get packaged into chylomicrons for distribution to the lymphatics.Author: Michael J. Hackett, Jennica L. Zaro, Wei-Chiang Shen, Patrick C. Guley, Moo J. Cho
https://cen.acs.org/pharmaceuticals/drug-delivery/Fatty-acid-drug-conjugate-kills/97/web/2019/08
Aug 21, 2019 · Making drugs more hydrophobic by coupling them to a fatty acid is a common drug-delivery process, Gianneschi says, but they’ve made some tweaks to …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287280/
Oct 01, 2014 · Other advantages of lipid modification that are exploited when applied to prodrugs include enabling targeting tumor sites, the liver, or the lymphatic system. Many different types of lipid molecules are available, from simple fatty acid conjugation to complex lipoprotein particles, for use in drug delivery.Author: Jennica L. Zaro
https://pubs.acs.org/doi/10.1021/acsomega.7b02061
Fluorescence probes are usually employed to analyze pharmacokinetics of drug carriers; however, this method using usual probes is not suitable to monitor drug carriers in detail because fluorescence spectra do not change by the disruption of drug carriers. In this study, pyrene–fatty acid conjugates were investigated as probes to monitor the state of drug carriers in real time. 1 ...Author: Keita Hayashi, Yuma Mitsuyoshi, Toshiyuki Kamei, Toshinori Shimanouchi, Keishi Suga, Yukihiro Okamot...
https://pubs.acs.org/doi/10.1021/cen-09733-scicon7
Aug 26, 2019 · Chemists want to trick cancer cells into taking up drug molecules by attaching the payloads to fatty acids, which the cells can quickly metabolize for energy. But scientists say it has been challenging to develop a fatty acid–based drug-delivery system that cells will reliably take up. Now, a team of researchers has improved on this method by using a more realistic fatty acid structure as ...Author: Megha Satyanarayana
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