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https://www.jabfm.org/content/17/4/306
Jul 01, 2004 · Factor V Leiden mutation (FVL) is an autosomal dominant hemostatic disorder that predisposes affected persons to venous thromboembolic events (VTE). Although the mutation causing FVL is easily diagnosed using molecular DNA techniques,[1][1] …Author: Robert C. Langan
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC116643/
Jul 09, 2002 · FACTOR V LEIDEN IS A COMMON GENETIC MUTATION that predisposes its carriers to venous thromboembolism. When combined with the hypercoagulable state that is characteristic of pregnancy, there is an increased risk of severe and recurrent pregnancy complications. Factor V Leiden is the most common cause ...
https://academic.oup.com/qjmed/article/99/5/289/2261125
Apr 13, 2006 · Abstract. Background: The factor V Leiden (FVL) mutation is the most common cause of inherited thrombophilia in Caucasian populations, and women with this variant allele are at increased risk for pregnancy complications. Aim: To examine whether the FVL allele is associated with pregnancy complications and adverse outcomes in a population-based study, and to identify potential factors that ...Author: E. Nurk, G.S. Tell, H. Refsum, P.M. Ueland, S.E. Vollset
https://community.whattoexpect.com/forums/december-2017-babies/topic/pregnancy-with-factor-v-leiden-gene-mutation.html
Hi all, so I'm almost 24 weeks with my second pregnancy and was recently diagnosed as having one gene mutation of factor v Leiden. I was tested due to having a family history of blood clots (probably should have been tested during my first pregnancy...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715853/
Jan 16, 2016 · As shown in Table 5, in a systematic review of nine case control studies (n = 2526) that evaluated the association between thrombophilia and pregnancy-associated VTE, the highest risks were associated with homozygosity for factor V Leiden or the prothrombin G20210A variant . Pregnant women with the most common heritable thrombophilias (i.e ...Author: Shannon M. Bates, Saskia Middeldorp, Marc Rodger, Andra H. James, Ian Greer
https://rarediseases.info.nih.gov/diseases/6403/factor-v-leiden-thrombophilia
Jul 05, 2019 · Factor V Leiden thrombophilia is a genetic disorder that makes it more likely for you to develop a blood clot sometime during your life.Still, it is estimated that 95% of people with factor V Leiden never develop a clot. When a clot does form, the clot most often occurs in your leg (deep venous thrombosis or DVT) or lungs (pulmonary embolism or PE).
https://www.sciencedirect.com/science/article/pii/S0002937810010008
Factor V Leiden mutation and pregnancy-related complications Presented at the 41st Nordic Coagulation Meeting, Gothenburg, Sweden, May 21-23, 2008, and at the Third International Symposium on Women's Health Issues in Thrombosis and Haemostasis, Prague, Czech Republic, Feb. 6-8, 2009.Author: Ulla Kjellberg, Marianne van Rooijen, Katarina Bremme, Margareta Hellgren
https://en.wikipedia.org/wiki/Factor_V_Leiden
Factor V Leiden (rs6025 or F5 p.R506Q) is a variant (mutated form) of human factor V (one of several substances that helps blood clot), which causes an increase in blood clotting (hypercoagulability).Due to this mutation, Protein C, an anticoagulant protein which normally inhibits the pro-clotting activity of factor V, is not able to bind normally to Factor V, leading to a hypercoagulable ...
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