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https://www.reviewofophthalmology.com/article/into-the-eye-two-new-ways-to-deliver-drugs
Jan 22, 2010 · The EyeGate II iontophoresis drug delivery device uses electrochemical repulsion to drive charged drug molecules out of a solvent solution and into the eye. The instrument features a small ocular applicator that's hollow in the center, with a doughnut-shaped foam reservoir that holds the solution containing the drug.
https://www.sciencedirect.com/topics/nursing-and-health-professions/drug-delivery-system
Drug Delivery System. A drug delivery system (DDS) is defined as a formulation or a device that enables the introduction of a therapeutic substance into the body and improves its efficacy and safety by controlling the rate, time, and place of release of drugs in the body.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289909/
The major challenge faced by today’s pharmacologist and formulation scientist is ocular drug delivery. Topical eye drop is the most convenient and patient compliant route of drug administration, especially for the treatment of anterior segment diseases.Author: Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra
iVeena develops ocular drug products that eliminate the need to apply eye drops and painful injections. iVeena also develops implants that deliver drugs more efficiently to the front and back of the eye.
https://www.reviewofophthalmology.com/article/in-eye-drug-delivery-more-new-ideas
Jul 15, 2010 · In-Eye Drug Delivery: More New Ideas ... the group compared the half life of Avastin molecules in Brown Norway rat eyes after injection. In the rats receiving standard Avastin, the drug was found to be present in the rat vitreous at one hour, but not at one week. Rats receiving Super Avastin demonstrated focal areas of fluorescent staining both ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895432/
May 01, 2010 · Ocular drug delivery has been a major challenge to pharmacologists and drug delivery scientists due to its unique anatomy and physiology. Static barriers (different layers of cornea, sclera, and retina including blood aqueous and blood–retinal barriers), dynamic barriers (choroidal and conjunctival blood flow, lymphatic clearance, and tear dilution), and efflux pumps in conjunction pose a ...Author: Ripal Gaudana, Hari Krishna Ananthula, Ashwin Parenky, Ashim K. Mitra
https://www.nibib.nih.gov/science-education/science-topics/drug-delivery-systems-getting-drugs-their-targets-controlled-manner
Drug delivery systems are engineered technologies for the targeted delivery and/or controlled release of therapeutic agents. Drugs have long been used to improve health and extend lives. The practice of drug delivery has changed dramatically in the past few decades and even greater changes are …
https://www.sciencedirect.com/science/article/pii/B9781907568862500010
Other routes of drug delivery to the eye are oral, intravenous, intravitreal, subconjunctival and periocular injections or implants . A challenging task in drug delivery is to overcome ocular barriers and deliver drugs efficiently to the targeted ocular tissue.Author: Kishore Cholkar, Supriya Reddy Dasari, Dhananjay Pal, Ashim K. Mitra
https://eye.hms.harvard.edu/topic/drug-delivery-medical-devices
We hypothesized that a drug-eluting contact lens that rests on the cornea would therefore be well-suited for delivering drugs to the eye including the retina. We developed a contact lens based dexamethasone delivery system (Dex-DS) that achieved sustained drug delivery to the retina at therapeutic levels.
https://www.drugdeliverybusiness.com/johnson-johnson-touts-drug-releasing-lens-studies-for-itchy-eyes/
Mar 26, 2019 · Contact lenses imbued with an antihistamine drug reduced itchy eyes in a pair of older studies funded by the vision business at Johnson & Johnson (NYSE:JNJ), the company said today. The Phase 3 studies, conducted in 2007, involved a total of 244 patients, divided into three cohorts. In the first patients wore a plain lens […]
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