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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289909/
Concentration of drug available in the precorneal area acts as a driving force for its passive diffusion across cornea. However, for efficient ocular drug delivery with eye drops, high corneal permeation with longer drug cornea contact time is required. Several efforts have been made toward improving precorneal residence time and corneal ...Author: Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra
iVeena develops ocular drug products that eliminate the need to apply eye drops and painful injections. iVeena also develops implants that deliver drugs more efficiently to the front and back of the eye.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895432/
May 01, 2010 · Ocular drug delivery has been a major challenge to pharmacologists and drug delivery scientists due to its unique anatomy and physiology. Static barriers (different layers of cornea, sclera, and retina including blood aqueous and blood–retinal barriers), dynamic barriers (choroidal and conjunctival blood flow, lymphatic clearance, and tear dilution), and efflux pumps in conjunction pose a ...Author: Ripal Gaudana, Hari Krishna Ananthula, Ashwin Parenky, Ashim K. Mitra
http://www.eyegatepharma.com/
EyeGate Pharma (NASDAQ: EYEG) is a late-stage clinical company focused on developing for treating disorders of the eye. EyeGate’s lead product, Ocular Bandage Gel (“OBG”), is based on a modified form of the natural polymer hyaluronic acid, which is a gel that possesses unique properties providing hydration and healing when applied to the ocular surface.
https://www.sciencedirect.com/topics/nursing-and-health-professions/drug-delivery-system
Drug Delivery System. A drug delivery system (DDS) is defined as a formulation or a device that enables the introduction of a therapeutic substance into the body and improves its efficacy and safety by controlling the rate, time, and place of release of drugs in the body.
http://samples.jbpub.com/9781284025682/9781449674250_CH10.pdf
Ocular Drug Delivery AswAni Dutt VADlApuDi, Kishore CholKAr, supriyA reDDy DAsAri, AnD Ashim K. mitrA CHAPTER OBJECTIVES Upon completing this chapter, the reader should be able to Describe the anatomy and physiology of the eye. Understand the importance of various routes of drug administration to the eye. Describe various barriers to ocular drug delivery and constraints with
https://www.eyeworld.org/article-novel-drug-delivery-systems-in-glaucoma
GLAUCOMA Novel drug delivery systems in glaucoma by Tony Realini, M.D. Taking patient compliance out of the equation Anecortave acetate, a drug that has been shown to lower IOP, is injected into a patient’s eye Source: Gregory Katz, M.D. Source: Gregory Katz, M.D. It is no secret that compliance with medical therapy is suboptimal among patients with glaucoma.
https://eye.hms.harvard.edu/topic/drug-delivery-medical-devices
We hypothesized that a drug-eluting contact lens that rests on the cornea would therefore be well-suited for delivering drugs to the eye including the retina. We developed a contact lens based dexamethasone delivery system (Dex-DS) that achieved sustained drug delivery to the retina at therapeutic levels.
https://www.sciencedirect.com/science/article/pii/S0753332218306863
Major proportion of market of ophthalmic products is occupied by topical formulations which includes eye drops (major), eye ointments, contact lens, cul-de-sac inserts, punctual plugs etc. Being the most convenient and efficacious non-invasive route, it is the most preferred especially for drug delivery to anterior segment.Author: Kritika Nayak, Manju Misra
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