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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894729/
The osmotic drug delivery systems suitable for oral administration typically consist of a compressed tablet core that is coated with a semipermeable membrane that has an orifice drilled on it by means of a laser beam or mechanical drill. Ketorolac is a nonsteroidal agent with powerful analgesic.
https://ijpras.com/storage/models/article/wcvDGp04NwBZ0OAlbaOx6WMrNeVmOqHtaYpRUPO20bxvtjblJuXPWL5QqwxE/osmotic-drug-delivery-system-an-overview.pdf
The oral route is the most common and most acceptable route of drug administration. For treatment of chronic diseases repeated dose administration is required, the osmotic drug delivery system serve as a tool for control release of drugs in these condition and avoid the repeated administration.File Size: 131KB
https://www.sciencedirect.com/science/article/pii/S0939641104000347
Osmotically controlled oral drug delivery systems (OCODDS) utilize osmotic pressure as the energy source for the controlled delivery of drugs. Drug release from these systems is independent of pH and hydrodynamic conditions of the gastro-intestinal tract (GIT) to a large extent, and release characteristics can be easily adjusted by optimizing ...Author: Rajan K Verma, Sanjay Garg
http://ijpsr.com/bft-article/oral-osmotic-drug-delivery-system-a-review/?view=fulltext
Osmotic drug delivery devices are composed of an osmotically active drug core, which is surrounded by a rate controlling semipermeable membrane. Osmotic drug delivery system differ from diffusion based systems in that the way of delivery of the active agents is driven by an osmotic gradient somewhat than the concentration of drug in the device.
https://www.researchgate.net/publication/317616211_Osmotic_Drug_Delivery_Systems_A_Review
Osmotic drug delivery systems release the drug with the zero order kinetics which does not depend on the initial concentration and the physiological factors of GIT.Author: Pallavi Kurra
http://ijpsr.com/bft-article/formulation-and-evaluation-of-controlled-porosity-osmotic-drug-delivery-system-of-metoprolol-succinate/?view=fulltext
Candidate drugs for osmotic drug delivery have water solubilities of 50-300 mg/ml. High soluble drugs would show a high release rate that would be zero order release for very small percentage of initial drug load. Thus intrinsic water solubility of many drugs might preclude them from incorporation into osmotic drug delivery system.
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