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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289909/
CONVENTIONAL OCULAR DRUG DELIVERY SYSTEMS. Topical drop instillation into the lower precorneal pocket is a patient compliant and widely recommended route of drug administration. However, most of the topically administered dose is lost due to reflux blinking and only 20% (−7 μL) of instilled dose is retained in the precorneal pocket ...Author: Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499423/
Introduction. Due to the poor drug bioavailability, ocular drug delivery still faces many challenges which can be the result of ocular anatomy, physiology and efficient protective mechanism including extensive nasolachrymal drainage, tear dynamics, relative impermeability of the corneal epithelial membrane and the high efficiency of the blood–ocular barrier.Author: Zahra Jafariazar, Nasim Jamalinia, Fatemeh Ghorbani-Bidkorbeh, Seyed Alireza Mortazavi
https://journals.sagepub.com/doi/pdf/10.1177/0192623307310955
Particulate ocular drug delivery systems include nanoparti-cles (1 to 1,000 nm) and microparticles (1 to 1,000 µm), which are further categorized as nanospheres and microspheres and nanocapsules and microcapsules (Bourges et al., 2006). ... Safety Evaluation of Ocular Drug .
https://www.researchgate.net/publication/225897418_OCULAR_DRUG_DELIVERY_SYSTEM_-_A_REVIEW
A successful design of a drug delivery system, therefore, requires an integrated knowledge of the drug molecule and the constraints offered by the ocular route of administration [3].
https://www.slideshare.net/vijayalakshmikalaga/ocular-drug-delivery-systems
Sep 17, 2012 · ocular drug delivery systems 1. INTRODUCTION Ocular administration of drug isprimarily associated with the need totreat ophthalmic diseases. Eye is the most easily accessible site fortopical administration of a medication. Ideal ophthalmic drug delivery mustbe able to sustain the drug release andto remain in the vicinity of front of theeye for prolong period of time.
https://www.slideshare.net/sujitpatel11/ocular-drug-delivery-system
Feb 10, 2013 · Ocular drug delivery system 1. Presented by:-Sujit R. Patel,Dept. of Pharmaceutics,Maratha Mandal College Of Pharmacy,Belgaum-590 010. 2. Contents:- Anatomy of eye Introduction Advantages Disadvantages Classification Evaluation of ocular drug delivery system Future trends ConclusionFebruary 11, 2013 Dept.
https://www.researchgate.net/publication/26316954_Development_and_evaluation_of_ocular_drug_delivery_system
Development and evaluation of ocular drug delivery system Article in Pharmaceutical Development and Technology 15(1):46-52 · June 2009 with 400 Reads How we measure 'reads'
http://ijpsr.com/bft-article/ocular-drug-delivery-system-an-overview/?view=fulltext
INTRODUCTION: In ocular drug delivery system, there is a main problem of rapid and extensive elimination of conventional eye drops from the eye 1-3.This problem results in extensive loss of drug. Only a few amount of drug penetrates the corneal layer and reached to internal tissue of eye 4-5.The main region of drug loss includes lachrymal drainage and drug dilution by tears 6.
https://journals.sagepub.com/doi/full/10.1177/0192623307310955
Jan 01, 2008 · Particulate ocular drug delivery systems include nanoparticles (1 to 1,000 nm) and microparticles (1 to 1,000 μm), which are further categorized as nanospheres and microspheres and nanocapsules and microcapsules (Bourges et al., 2006). Nanospheres and microspheres are a polymer–drug combination in which the drug is homogenously dispersed in ...Author: Brian G. Short
https://www.sciencedirect.com/science/article/pii/S0168365919302901
In addition to ocular drug delivery systems such as colloids [16,18] and polymeric implants , hydrogels are another class of material that offer favorable properties for sustained drug release . Composed of a three-dimensional network of hydrophilic polymer chains, hydrogels have a high capacity for water retention.Author: Remy C. Cooper, Hu Yang
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