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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499423/
Introduction. Due to the poor drug bioavailability, ocular drug delivery still faces many challenges which can be the result of ocular anatomy, physiology and efficient protective mechanism including extensive nasolachrymal drainage, tear dynamics, relative impermeability of the corneal epithelial membrane and the high efficiency of the blood–ocular barrier.Author: Zahra Jafariazar, Nasim Jamalinia, Fatemeh Ghorbani-Bidkorbeh, Seyed Alireza Mortazavi
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289909/
The major challenge faced by today’s pharmacologist and formulation scientist is ocular drug delivery. Topical eye drop is the most convenient and patient compliant route of drug administration, especially for the treatment of anterior segment diseases.Author: Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra
https://www.slideshare.net/AnalMondal1/evaluation-of-ocular-drug-delivery-system-112466542
Aug 31, 2018 · Evaluation Of Ocular Drug Delivery System 1. Bengal School of Technology A Presentation submitted on - EVALUATION OF OCULAR DRUGS DELIVERY SYSTEM Name- ANAL MONDAL M.PHARM PHARMACEUTICS 2. INTRODUCTION Ocular administration of drug is primarily associated with the need to treat ophthalmic diseases. Eye is the most easily accessible site for ...
https://www.researchgate.net/publication/225897418_OCULAR_DRUG_DELIVERY_SYSTEM_-_A_REVIEW
A successful design of a drug delivery system, therefore, requires an integrated knowledge of the drug molecule and the constraints offered by the ocular route of administration [3].
https://www.slideshare.net/vijayalakshmikalaga/ocular-drug-delivery-systems
Sep 17, 2012 · ocular drug delivery systems 1. INTRODUCTION Ocular administration of drug isprimarily associated with the need totreat ophthalmic diseases. Eye is the most easily accessible site fortopical administration of a medication. Ideal ophthalmic drug delivery mustbe able to sustain the drug release andto remain in the vicinity of front of theeye for prolong period of time.
https://journals.sagepub.com/doi/pdf/10.1177/0192623307310955
Safety Evaluation of Ocular Drug Delivery Formulations: Techniques and Practical Considerations BRIAN G. SHORT From Allergan, Inc., Irvine, California, USA. ABSTRACT Development of new drug candidates and novel delivery techniques for treatment of ocular diseases has …
https://www.researchgate.net/publication/26316954_Development_and_evaluation_of_ocular_drug_delivery_system
The formulation was found to be practically nonirritant in ocular irritation studies. AZT can therefore be developed as an ocular insert delivery system for the treatment of ocular surface infections.
http://ijpsr.com/bft-article/ocular-drug-delivery-system-an-overview/?view=fulltext
INTRODUCTION: In ocular drug delivery system, there is a main problem of rapid and extensive elimination of conventional eye drops from the eye 1-3.This problem results in extensive loss of drug. Only a few amount of drug penetrates the corneal layer and reached to internal tissue of eye 4-5.The main region of drug loss includes lachrymal drainage and drug dilution by tears 6.
http://www.irjpbs.com/volumes/vol4/issue3/IRJPBS-4303.pdf
Ashir TP et al., 2017/ Review on approaches and evaluation of in-situ ocular. International Research Journal of Pharmaceutical and Biosciences (IRJPBS) 4 (3) 24 . delivery of required dose and also to prolong contact time of drug in contact with mucosal layer of eye. These problems generally occurred in the case of liquid dosage and semi-solid
https://journals.sagepub.com/doi/full/10.1177/0192623307310955
Jan 01, 2008 · Novel ocular drug-delivery formulations and methods for localized, sustained delivery may provide the solution for treating serious intraocular diseases. Although regulatory guidance is sparse for ocular drugs, review of FDA Pharmacology Reviews and selected literature can provide insights.Author: Brian G. Short
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