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    Jun 22, 2018 · Oral Medications for Erectile Dysfunction Catered To The Individual. Patients may be familiar with brand-name solutions to their diagnosis, but compounded solutions of these PDE5 inhibitors, namely, sildenafil and tadalafil, offer prescribers and patients new opportunities for care including: Faster onset. When medications are compounded in sublingual troches, patients …

Rapid-Onset Sildenafil Sublingual Drug Delivery Systems ...

    https://www.sciencedirect.com/science/article/pii/S0022354916003117
    The aim of the present study was to prepare sublingual delivery systems for sildenafil and evaluate its relative bioavailability after sublingual administration in rabbits to attain a rapid onset of action with good efficacy at lower doses.Author: Ming Thau Sheu, Chien Ming Hsieh, Ray Neng Chen, Po Yu Chou, Hsiu O. Ho

Sublingual Administration of Sildenafil Oro-dispersible ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808105/
    Feb 06, 2018 · Objective: Type 5 phosphodiesterase inhibitors (PDE5i) are efficient drugs used for treatment of erectile dysfunction (ED); however, a large discontinuation rate due to major side effects is reported. The aim of this study was to evaluate the possible improvement of sildenafil (Sild) pharmacokinetics associated to the sublingual administration of the new available oro-dispersible film …Author: Luca De Toni, Maurizio De Rocco Ponce, Erica Franceschinis, Stefano Dall’Acqua, Roberto Padrini, Nic...

Advances in Nanoparticulate Drug Delivery Approaches for ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848967/
    Nov 05, 2019 · Physiological Factors Influencing Sublingual and Buccal Drug Delivery. For effective drug delivery via the sublingual or buccal route of administration, several physiological factors should be considered in drug formulation design and development. These factors may influence drug bioavailability, stability, efficacy, and safety.Author: Susan Hua

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    May 24, 2019 · Erectile dysfunction (ED) is highly prevalent in diabetes mellitus. Pathophysiological mechanisms underlying diabetes-associated ED are in large part due to endothelial dysfunction, which functionally refers to the inability of the endothelium to produce vasorelaxing messengers and to maintain vasodilation and vascular homeostasis.

Sublingual sildenafil in the treatment of erectile ...

    https://www.researchgate.net/publication/8208438_Sublingual_sildenafil_in_the_treatment_of_erectile_dysfunction_Faster_onset_of_action_with_less_dose
    20 mg sublingual sildenafil is safe and effective in the treatment of erectile dysfunction. Sublingual administration has some advantages as it is not effected by food ingestion and quickly appears in the circulation. These advantages provide a faster onset of action with a lower dose when compared to oral sildenafil.

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