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https://www.sciencedirect.com/science/article/pii/S0169409X03002436
Electroporation is an efficient method for enhancing transdermal drug delivery in vitro and in vivo, and expands the range of compounds delivered transdermally. It could be a promising alternative as a non-invasive delivery of macromolecules (up to at least 40 kDa) …Author: Anne-Rose Denet, Rita Vanbever, Véronique Préat
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810085/
Mar 17, 2016 · The above-mentioned reports indicate that in certain scenarios, the combination of electroporation with other transdermal drug delivery techniques may lead to percutaneous transport enhancement. Several variables are involved and synergistic flux …Author: Kevin B. Ita
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC47805/
Nov 15, 1993 · Electroporation of mammalian skin: a mechanism to enhance transdermal drug delivery. M R Prausnitz, V G Bose, R Langer, and J C Weaver ... Electroporation is the creation of aqueous pores in lipid bilayers by the application of a short (microseconds to milliseconds) electric pulse. Our measurements suggest that electroporation occurs in the ...Author: M R Prausnitz, V G Bose, R Langer, J C Weaver
https://link.springer.com/chapter/10.1007/978-3-662-53273-7_7
May 05, 2017 · This chapter presents the mechanism of percutaneous penetration enhancement induced by electroporation, discusses factors influencing percutaneous penetration of drug molecules, addresses effects of electroporation on the skin when used in vivo, and describes the potential use of electroporation for transdermal drug delivery.Author: Babu M. Medi, Buddhadev Layek, Jagdish Singh
http://www.eurekaselect.com/92456
The application of electroporation to enhance transdermal delivery has opened up a new possibility to introduce larger molecules such as peptide hormones and vaccines as well as minigenes and RNAi etc. through the transdermal route. Many devices have been developed to deliver the pulse electric field needed to permeate the skin.Author: Sek-Wen Hui, Tak-Wah Wong, Shu-Fen Ko
https://www.sciencedirect.com/science/article/abs/pii/S0168365905006425
A microelectrode array was designed to minimize the pain sensation of electroporation for enhancing transdermal drug delivery. The influence of the size of the electrode–skin contact area and of the distance between electrodes on the pain sensation was tested on human volunteers.Author: Tak Wah Wong, Ching Hung Chen, Chien Chun Huang, Cheng De Lin, Sek Wen Hui
https://www.intechopen.com/books/application-of-nanotechnology-in-drug-delivery/electroporation-advantages-and-drawbacks-for-delivery-of-drug-gene-and-vaccine
Furthermore, electroporation is an efficient method for enhancing transdermal drug delivery in vitro and in vivo and expands the range of compounds delivered transdermally. The combined use of electroporation with other physical enhancers such as iontophoresis is likely to yield useful and interesting data, to further explore electroporation as ...Author: Azam Bolhassani, Afshin Khavari, Zahra Orafa
https://www.researchgate.net/publication/41450425_Electroporation_An_Avenue_for_Transdermal_Drug_Delivery
The present article review the different methodologies used to surmount the inherent limitations imposed by stratum corneum of skin, for enhanced transdermal drug delivery to achieve systemic ...
https://www.researchgate.net/publication/7412801_Painless_electroporation_with_a_needle_free-microelectrode_array_to_enhance_transdermal_drug_delivery
A microelectrode array was designed to minimize the pain sensation of electroporation for enhancing transdermal drug delivery. The influence of the size of the electrode-skin contact area and of ...
http://www.thno.org/v08p3688.pdf
Key words: transdermal drug delivery, gene delivery, electroporation, microneedle Introduction Transdermal drug delivery provides an alternative to oral administration and hypodermic injections to enhance bioavailability, coupled with the advantages of the user-friendly route and improved patient compliance [2, 3]. In the past few decades,
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