Engineered Antibodies For Drug Delivery

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Engineered antibodies Nature Medicine

    https://www.nature.com/articles/nm0103-129
    For cancer therapy, bifunctional antibodies are engineered to effectively target tumor-associated antigens at low levels and then deliver a cytotoxic payload to tumor cells. The latest...

Engineered Biological Entities for Drug Delivery and Gene ...

    https://www.sciencedirect.com/science/article/pii/B9780124160200000061
    Ideal drug delivery and gene therapy vehicles must accomplish some desired features such as appropriate packaging size for its cargo, target cell-specificity, safe and efficient cargo delivery, and protection against immune recognition, or capability to escape immune recognition.Author: Joan Domingo-Espín, Joan Domingo-Espín, Ugutz Unzueta, Ugutz Unzueta, Paolo Saccardo, Paolo Saccardo...

Nanocell targeting using engineered bispecific antibodies

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622061/
    Dec 18, 2014 · A myriad of engineered NPs for drug delivery have been developed, and include liposomes, polymeric-based NPs, silica, carbon, metal oxides and other materials. Some are also derived from bacteria, viruses (e.g., virus-like particles) and eukaryotic cells (exosomes).

Engineered Nanoparticles for Drug Delivery in Cancer ...

    https://www.onlinelibrary.wiley.com/doi/full/10.1002/anie.201403036
    Engineered Nanoparticles for Drug Delivery in Cancer Therapy. Dr. Tianmeng Sun. The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of …Author: Tianmeng Sun, Yu Shrike Zhang, Bo Pang, Dong Choon Hyun, Miaoxin Yang, Younan Xia, Younan Xia

Engineered exosomes for targeted co-delivery of miR-21 ...

    https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-019-0563-2
    Although there is no natural ligand, artificial ligands such as antibody, Fab, ScFv, affibody and peptide have been developed for Her2 targeted drug delivery. In this study, in order to endow the target specificity, exosomes were engineered to possess an anti-Her2 affibody on its surface, by fusing the affibody with LAMP2, an abundantly expressed surface protein of exosomes.

Lymphatic drug delivery using engineered liposomes and ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164476/
    Sep 10, 2011 · 1.2 Liposomal formulations for lymphatic drug delivery via the intestinal route. Oral delivery of therapeutics is the most convenient and widely employed route of drug delivery. However, a number of drugs exhibit poor oral bioavailability due to the degradation of the active drugs in the gastrointestinal tract.Author: Shuang Cai, Qiuhong Yang, Taryn R. Bagby, M. Laird Forrest

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