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https://www.diabetesdaily.com/blog/2015/10/implantable-insulin-capsule-could-replace-injectionspumps-in-type-1-diabetes/
Specifically for people with type 1 diabetes, the new device is called the “Encaptra drug delivery system.” Simply put, it’s a capsule, approximately the width of a credit card, that is implanted under the skin, in a location near the pancreas.
https://insulinnation.com/research/will-viacytes-encaptra-cell-delivery-system-cure-type-1-diabetes/
Mar 10, 2020 · One of the most notable efforts is ViaCyte’s Encaptra “cell delivery system.” This is different from the islet transplantation you have read about where keeping the islets healthy is difficult. Instead, ViaCyte transplants pancreatic beta-cell ‘precursors’ that mature in place as needed into islets.
http://diabetesdigest.com/implanted-islet-cells-for-type-1-diabetes-gets-approval-for-human-trials/
Within the Encaptra system are stem cells, called PEC-01 cells, which have been programmed to develop into insulin producing islet cells. The Encaptra system has life changing properties for people with type 1 diabetes as it allows insulin to pass out of the capsule, nutrients such as glucose and oxygen to pass into the capsule to feed the living cells yet protects the cells from the immune attack of type 1 …
https://viacyte.com/press-releases/viacyte-achieves-significant-milestone-with-iso-134852003-certification-for-its-encaptra-drug-delivery-system/
These cells are implanted in a durable and retrievable encapsulation device called the Encaptra® drug delivery system. Once implanted and matured, these cells are designed to secrete insulin and other regulatory factors in response to blood glucose levels.
http://www.diabetesincontrol.com/new-encapsulated-beta-cell-replacement-therapy-for-type-1-diabetes/
In addition to the IND, ViaCyte also submitted a Medical Device Master File (MAF) to the FDA regarding the Encaptra® drug delivery system, a device component of the VC-01 product. Beta cell encapsulation therapy is a procedure that involves implantation of cells with the ability to secrete insulin in a glucose-responsive manner in a protective barrier into the body.
https://www.marketwatch.com/press-release/viacyte-achieves-significant-milestone-with-iso-134852003-certification-for-its-encaptra-drug-delivery-system-2014-07-08
Jul 08, 2014 · The Company's lead product candidate, VC-01, is based on the production of pancreatic progenitors derived from human pluripotent stem cells. These cells are implanted in a durable and...
https://www.sandiegouniontribune.com/business/biotech/sd-me-biotech-adjustments-20161007-story.html
The device, called the Encaptra Drug Delivery System, is about 1/2 of a millimeter thick — thin enough to allow nutrients to flow in and hormones such as insulin to flow out by diffusion.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576846/
Implantable drug-delivery systems provide new means for achieving therapeutic drug concentrations over entire treatment durations in order to optimize drug action. This article focuses on new drug administration modalities achieved using implantable drug-delivery systems that are enabled by micro- and nano-fabrication technologies, and microfluidics.Author: Ellis Meng, Tuan Hoang
https://www.pharmatutor.org/articles/review-implantable-drug-delivery-system
Therefore, drug delivery systems were developed to optimize the therapeutic properties of drug products and render them more safe, effective, and reliable. In comparison with many of the other drug delivery systems, implantable pumps and implants for variable rate delivery …
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