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https://ohsu.pure.elsevier.com/en/publications/duodenal-and-gastric-delivery-of-levodopa-in-parkinsonism-2
To clarify the influence of gastric emptying on levodopa-related motor fluctuations in Parkinson's disease, we assessed mobility and plasma levodopa concentrations in 10 patients during five modes of levodopa administration: (1) standard intermittent oral (SIO), (2) intermittent duodenal (ID), (3) continuous duodenal infusion (CDI), (4) continuous gastric infusion (CGI), and (5) controlled ...Author: Roger Kurlan, John G. Nutt, William R. Woodward, Kenneth Rothfield, David Lichter, Charlyne Miller, ...
https://www.ncbi.nlm.nih.gov/pubmed/3752968
The pathogenesis of on-off motor fluctuations in parkinsonism remains incompletely understood, but slowed or erratic gastric emptying of orally administered levodopa may be involved. In 3 patients with resistant on-off fluctuations, direct duodenal continuous infusion of levodopa via a nasoduodenal tube resulted in a heightened therapeutic effect, including a reduction in motor fluctuations.Author: Roger Kurlan, Allen J. Rubin, Charlyne Miller, Leonor Rivera‐Calimlim, Allan Clarke, Ira Shoulson
https://onlinelibrary.wiley.com/doi/10.1002/ana.410200213
The pathogenesis of on‐off motor fluctuations in parkinsonism remains incompletely understood, but slowed or erratic gastric emptying of orally administered levodopa may be involved. In 3 patients with resistant on‐off fluctuations, direct duodenal continuous infusion of levodopa via a nasoduodenal tube resulted in a heightened therapeutic effect, including a reduction in motor fluctuations.Author: Roger Kurlan, Allen J. Rubin, Charlyne Miller, Leonor Rivera‐Calimlim, Allan Clarke, Ira Shoulson
https://www.deepdyve.com/lp/wiley/duodenal-and-gastric-delivery-of-levodopa-in-parkinsonism-0eILX0cVVp
Read "Duodenal and gastric delivery of levodopa in parkinsonism, Annals of Neurology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1011414/
Pharmacotherapy with levodopa for Parkinson's disease provides symptomatic benefit, but fluctuations in (or loss of) response may eventually occur. Dopamine agonists are also helpful and, when taken with low doses of levodopa, often provide sustained benefit with fewer side effects; novel agonists and new methods for their administration are therefore under study.Author: M J Aminoff
https://www.ncbi.nlm.nih.gov/pubmed/17376020/
Motor fluctuations are a common problem in the long-term management of Parkinson's disease (PD), resulting in disability and impaired quality of life. The relatively short serum half-life (approximately 90 min) of oral levodopa/carbidopa and its erratic absorption due to delayed and inconsistent gastric emptying (a non-motor feature of PD) are thought to be important factors in the development of motor …Author: Johan Samanta, Robert A Hauser
https://www.ncbi.nlm.nih.gov/pubmed/23948989
Jan 01, 2013 · Levodopa, a dopamine precursor, is an effective and well-tolerated dopamine replacement agent used to treat Parkinson's disease (PD). Oral levodopa has been widely used for over 40 years, often in combination with a dopa-decarboxylase inhibitor (DDCI), which reduces many treatment complications, extending its half-life and increasing levodopa ...Author: David Salat, Eduardo Tolosa
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027699/
Duodenal levodopa infusion. Constant levodopa infusion aims to achieve continuous delivery with an optimised dose that can be kept stable within the patient’s individual therapeutic window. Gastric emptying must be bypassed to achieve this.Author: Angelo Antonini
https://www.researchgate.net/publication/21394863_Clinical_and_pharmacokinetic_comparison_of_oral_and_duodenal_delivery_of_levodopacarbidopa_in_patients_with_Parkinson's_disease_with_a_fluctuating_response_to_levodopa
Clinical and pharmacokinetic comparison of oral and duodenal delivery of levodopa/carbidopa in patients with Parkinson's disease with a fluctuating response to levodopa
https://www.healthline.com/health/parkinsons/treatments/pump-delivered-therapy
The current FDA-approved version for pump delivery is a gel called Duopa. Symptoms of Parkinson’s, like tremors, trouble moving, and stiffness, are caused by your brain not having enough dopamine, a chemical the brain normally has. Because your brain can’t be given more dopamine directly,...Author: Rena Goldman
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