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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895432/
May 01, 2010 · Ocular drug delivery has been a major challenge to pharmacologists and drug delivery scientists due to its unique anatomy and physiology. Static barriers (different layers of cornea, sclera, and retina including blood aqueous and blood–retinal barriers), dynamic barriers (choroidal and conjunctival blood flow, lymphatic clearance, and tear dilution), and efflux pumps in conjunction pose a ...Author: Ripal Gaudana, Hari Krishna Ananthula, Ashwin Parenky, Ashim K. Mitra
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289909/
The highly branched structure of dendrimers allows incorporation of wide range of drugs, hydrophobic as well as hydrophilic. In ocular drug delivery, few promising results were reported with these branched polymeric systems [4,92,93]. Poly (amidoamine) (PAMAM) dendrimers are …Author: Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra
https://www.sciencedirect.com/topics/medicine-and-dentistry/ocular-drug
However, increasing the viscosity of the delivery solution only produces a modest gain in ocular drug absorption, particularly for lipid-soluble drugs. The residence time for many drugs is especially reduced by their pH, tonicity and the direct effect of certain drugs on lacrimation, which all affect the residence time of drugs in the lower fornix.
https://www.researchgate.net/publication/225897418_OCULAR_DRUG_DELIVERY_SYSTEM_-_A_REVIEW
OCULAR DRUG DELIVERY SYSTEM – A REVIEW ... The first one is based on the use of sustained drug delivery systems, which provide the controlled and continuous delivery of ophthalmic drugs. The ...
https://www.slideshare.net/vijayalakshmikalaga/ocular-drug-delivery-systems
Sep 17, 2012 · ocular drug delivery systems 1. INTRODUCTION Ocular administration of drug isprimarily associated with the need totreat ophthalmic diseases. Eye is the most easily accessible site fortopical administration of a medication. Ideal ophthalmic drug delivery mustbe able to sustain the drug release andto remain in the vicinity of front of theeye for prolong period of time.
https://journals.sagepub.com/doi/pdf/10.1177/0192623307310955
Vol. 36, No. 1, 2008 OCULAR DRUG DELIVERY FORMULATIONS 51 FIGURE 3.—Sites and methods for ocular drug delivery to the eye. Various methods for delivery of drugs to the anterior and posterior chambers of the eye are illustrated, including sites for conventional drug delivery as well as newer routes. Reproduced by permission from Davis et al ...
https://www.ondrugdelivery.com/ocular-drug-delivery-technologies-exciting-times-ahead/
Yasin MN, Svirskis D, Seyfoddin A, Rupenthal ID, “Implants for drug delivery to the posterior segment of the eye: A focus on stimuli-responsive and tunable release systems”. Journal of Controlled Release, 2014, Vol 196, pp 208-221. O’Rourke M, Hanes J, “Ocular Drug Delivery Via Micro- and Nanoparticles”.
https://www.ijpbs.com/ijpbsadmin/upload/ijpbs_50c8546501de1.pdf
delivery. Drug delivery to eye has always been a daunting task in the field of pharmaceutical research due to unique anatomy and physiology of the eye. One of the major problems encountered by conventional ocular dosage forms include rapid precorneal drug loss due to nasolacrimal drainage, tear turnover and drug dilution resulting in
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